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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1997-6-20
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pubmed:abstractText |
Major histocompatibility complex (MHC) class I-deficient cell lines were used to demonstrate that the MHC class II transactivator (CIITA) can induce surface expression of MHC class I molecules. CIITA induces the promoter of MHC class I heavy chain genes. The site alpha DNA element is the target for CIITA-induced transactivation of class I. In addition, interferon-gamma (IFNgamma)-induced MHC class I expression also requires an intact site alpha. The G3A cell line, which is defective in CIITA induction, does not induce MHC class I antigen and promoter in response to IFNgamma. Trans-dominant-negative forms of CIITA reduce class I MHC promoter function and surface antigen expression. Collectively, these data argue that CIITA has a role in class I MHC gene induction.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1074-7613
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
591-600
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9175837-Breast Neoplasms,
pubmed-meshheading:9175837-Carcinoma,
pubmed-meshheading:9175837-Chloramphenicol O-Acetyltransferase,
pubmed-meshheading:9175837-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:9175837-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:9175837-Genes, MHC Class II,
pubmed-meshheading:9175837-Genes, Reporter,
pubmed-meshheading:9175837-Histocompatibility Antigens Class I,
pubmed-meshheading:9175837-Humans,
pubmed-meshheading:9175837-Leukemia, Myelogenous, Chronic, BCR-ABL Positive,
pubmed-meshheading:9175837-Mutation,
pubmed-meshheading:9175837-Nuclear Proteins,
pubmed-meshheading:9175837-Promoter Regions, Genetic,
pubmed-meshheading:9175837-Trans-Activators,
pubmed-meshheading:9175837-Transcriptional Activation,
pubmed-meshheading:9175837-Tumor Cells, Cultured
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pubmed:year |
1997
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pubmed:articleTitle |
Induction of MHC class I expression by the MHC class II transactivator CIITA.
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pubmed:affiliation |
Lineberger Comprehensive Cancer Center, Department of Microbiology-Immunology, University of North Carolina at Chapel Hill, 27599-7295, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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