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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1997-6-18
|
| pubmed:abstractText |
Söderström bodies, also termed lymphoglandular bodies (LGB) and detectable in fine-needle aspiration cytology smears, have long been accepted as indicative of lymphoid tissues. To investigate the validity of this association, we examined 588 cytologic smears from high-grade non-Hodgkin's lymphoma (NHL), carcinoma, and sarcoma. Slides with lymphocytes in the vicinity of carcinoma and sarcoma cells had been excluded. Two independent observers scored smears to number, size, color, form, and smear background of the LGB. In 68 of 359 (19%) nonlymphoid malignancies rare (defined as < 1 LGB per high-power field) or occasional LGB (defined as 1-20 LGB per high-power field) were detectable. Half of these tumors consisted of melanomas, small cell lung carcinomas, and teratomas; the other half encompassed undifferentiated sarcomas. However, none of the smears obtained from carcinoma or sarcoma tissue had abundant LGB (defined as > 20 LGB per high-power field). When number of LGB was estimated to be abundant, the sensitivity for diagnosing a lymphoma was 54%; however, specificity was 100%. The difference in showing LGB between high-grade NHL and carcinoma/sarcoma was highly significant (p = 0.0001). The presence of abundant LGB in cytologic smears strongly suggests the diagnosis of lymphoma, while the absence of LGB nearly excludes this diagnosis. No trends were observed with the other criteria which were tested. LGB in aspiration cytology smears from malignant tumors thus represent a useful tool to distinguish high-grade NHL from carcinoma and sarcoma.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0939-5555
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
74
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
175-8
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9174545-Biopsy, Needle,
pubmed-meshheading:9174545-Carcinoma,
pubmed-meshheading:9174545-Carcinoma, Small Cell,
pubmed-meshheading:9174545-Cytodiagnosis,
pubmed-meshheading:9174545-Cytoplasmic Granules,
pubmed-meshheading:9174545-Diagnosis, Differential,
pubmed-meshheading:9174545-Humans,
pubmed-meshheading:9174545-Lung Neoplasms,
pubmed-meshheading:9174545-Lymphoma, Non-Hodgkin,
pubmed-meshheading:9174545-Melanoma,
pubmed-meshheading:9174545-Retrospective Studies,
pubmed-meshheading:9174545-Sarcoma,
pubmed-meshheading:9174545-Sensitivity and Specificity,
pubmed-meshheading:9174545-Teratoma
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
The abundant presence of Söderström bodies in cytology smears of fine-needle aspirates contributes to distinguishing high-grade non-Hodgkin's lymphoma from carcinoma and sarcoma.
|
| pubmed:affiliation |
Department of Internal Medicine III, University of Ulm, Germany.
|
| pubmed:publicationType |
Journal Article
|