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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1997-6-25
|
| pubmed:abstractText |
This randomized prospective study measured the effects of an intravenous opioid bolus on cerebrospinal fluid pressure (CSFP), mean arterial pressure (MAP), and cerebral perfusion pressure (CPP) during skull-pin insertion. Twenty-two adult patients scheduled for elective craniotomy for supratentorial lesions were studied. Outcome variables were MAP, heart rate (HR), and lumbar CSFP. The standardized anesthetic regimen included fentanyl (2 microg/kg), thiopental (5-7 mg/kg), lidocaine (1.5 mg/kg), isoflurane (0.3-0.7 minimum alveolar anesthetic concentration), and vecuronium (0.1 mg/kg). During stable anesthesia, sufentanil (0.8 microg/kg) or fentanyl (4.5 microg/kg) was given as a bolus before skull-pin insertion. The hemodynamic effects of the opioid injection were modified with phenylephrine and/or atropine when indicated. CSFP remained unchanged in both treatment groups. MAP and CPP increased approximately 10 mm Hg after skull-pin insertion (P<0.001). In the sufentanil group, HR decreased approximately 10 bpm after opioid injection and remained decreased throughout the study. In fentanyl-treated patients, HR decreased 8 bpm after opioid injection but returned to preopioid rates after skull-pin insertion. In conclusion, in anesthetized patients, an intravenous bolus of fentanyl or sufentanil prior to skull-pin insertion results in stable values of CSFP, CPP, BP, and HR when the hemodynamic effects of the opioid are modified with phenylephrine and atropine.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Anesthesia,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Analgesics, Opioid,
http://linkedlifedata.com/resource/pubmed/chemical/Atropine,
http://linkedlifedata.com/resource/pubmed/chemical/Fentanyl,
http://linkedlifedata.com/resource/pubmed/chemical/Phenylephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Sufentanil
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0003-2999
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
84
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1292-6
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9174309-Adjuvants, Anesthesia,
pubmed-meshheading:9174309-Adrenergic alpha-Agonists,
pubmed-meshheading:9174309-Adult,
pubmed-meshheading:9174309-Analgesics, Opioid,
pubmed-meshheading:9174309-Atropine,
pubmed-meshheading:9174309-Blood Pressure,
pubmed-meshheading:9174309-Bone Nails,
pubmed-meshheading:9174309-Cerebrospinal Fluid Pressure,
pubmed-meshheading:9174309-Cerebrovascular Circulation,
pubmed-meshheading:9174309-Craniotomy,
pubmed-meshheading:9174309-Double-Blind Method,
pubmed-meshheading:9174309-Fentanyl,
pubmed-meshheading:9174309-Heart Rate,
pubmed-meshheading:9174309-Humans,
pubmed-meshheading:9174309-Injections, Intravenous,
pubmed-meshheading:9174309-Intracranial Pressure,
pubmed-meshheading:9174309-Perfusion,
pubmed-meshheading:9174309-Phenylephrine,
pubmed-meshheading:9174309-Prospective Studies,
pubmed-meshheading:9174309-Skull,
pubmed-meshheading:9174309-Sufentanil
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
The effect of skull-pin insertion on cerebrospinal fluid pressure and cerebral perfusion pressure: influence of sufentanil and fentanyl.
|
| pubmed:affiliation |
Department of Anesthesiology, University of Paris-Sud, Le Kremlin Bicêtre, France.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial
|