Linked Life Data

9172452

Source:http://linkedlifedata.com/resource/pubmed/id/9172452

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11-12
pubmed:dateCreated
1997-7-10
pubmed:abstractText
Recent biochemical and genetic studies implicate Csk (carboxy-terminal Src kinase) as the one of the main downregulators of the activity of members of the Src family of kinases. Csk is probably involved in the downregulation of TCR signaling by C-terminal tyrosine phosphorylation of Lck and Fyn, but the mechanism whereby Csk targets these Src family members is not known. Here we report the association of Csk with the TCR complex, an interaction mediated by the binding of the Csk-SH2 domain to phosphorylated zeta and epsilon chains of the TCR complex. The interaction with TCR brings Csk into close contact with Lck and Fyn which are known to be associated with TCR, either functionally and/or physically. This finding suggests a novel mechanism whereby TCR signaling is turned off.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0024-3477
pubmed:author
pubmed:issnType
Print
pubmed:volume
118
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
264-71
pubmed:dateRevised
2011-11-2
pubmed:meshHeading
pubmed:articleTitle
CSK associates with the TCR zeta and epsilon chains via its SH2 domain; a mechanism for turning off TCR signaling.
pubmed:affiliation
Division of Clinical Immunology, Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't