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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1997-7-24
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pubmed:abstractText |
Three experiments tested the effects of recombinant bovine granulocyte-macrophage colony-stimulating factor (rbGM-CSF) on the preimplantation bovine and ovine conceptus. There was no effect of rbGM-CSF on the secretion of total radiolabeled protein in conditioned medium, immunoreactive interferon-tau (IFN tau), antiviral activity, or prostaglandin E2 from Day 16-18 bovine conceptuses cultured for 24 hr with, [3H]leucine and +/- 10 ng/ml rbGM-CSF. Similarly, there was no effect of 1 ng/ml rbGM-CSF on the secretion of total radiolabeled protein. IFN tau, or antiviral activity from Day 17 ovine conceptuses. There was also no beneficial effect of 1 or 10 ng/ml rbGM-CSF on the presence of immunoreactive IFN tau in conditioned medium from in vitro-produced bovine blastocysts at Day 7-8 after fertilization. Results indicate that IFN tau secretion from bovine and ovine conceptuses are unresponsive to rbGM-CSF at the concentrations tested.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0739-7240
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
193-7
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9171977-Animals,
pubmed-meshheading:9171977-Blastocyst,
pubmed-meshheading:9171977-Cattle,
pubmed-meshheading:9171977-Culture Media, Conditioned,
pubmed-meshheading:9171977-Dinoprostone,
pubmed-meshheading:9171977-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:9171977-Insemination, Artificial,
pubmed-meshheading:9171977-Interferon Type I,
pubmed-meshheading:9171977-Interferon-gamma,
pubmed-meshheading:9171977-Organ Culture Techniques,
pubmed-meshheading:9171977-Pregnancy Proteins,
pubmed-meshheading:9171977-Proteins,
pubmed-meshheading:9171977-Recombinant Proteins,
pubmed-meshheading:9171977-Swine
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pubmed:year |
1997
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pubmed:articleTitle |
Lack of effect of granulocyte-macrophage colony-stimulating factor on secretion of interferon-tau, other proteins, and prostaglandin E2 by the bovine and ovine conceptus.
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pubmed:affiliation |
Department of Dairy and Poultry Sciences, University of Florida, Gainesville 32611-0920, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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