Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1997-7-3
pubmed:abstractText
The urokinase-type plasminogen activator (uPA) and the matrix-degrading metalloproteinases MMP-2 and MMP-9 (type IV collagenases/gelatinases) have been implicated in a variety of invasive processes, including tumor invasion, metastasis and angiogenesis. MMP-2 and MMP-9 are secreted in the form of inactive zymogens that are activated extracellularly, a fundamental process for the control of their activity. The physiological mechanism(s) of gelatinase activation are still poorly understood; their comprehension may provide tools to control cell invasion. The data reported in this paper show multiple roles of the uPA-plasmin system in the control of gelatinase activity: (i) both gelatinases are associated with the cell surface; binding of uPA and plasmin(ogen) to the cell surface results in gelatinase activation without the action of other metallo- or acid proteinases; (ii) inhibition of uPA or plasminogen binding to the cell surface blocks gelatinase activation; (iii) in soluble phase plasmin degrades both gelatinases; and (iv) gelatinase activation and degradation occur in a dose- and time-dependent manner in the presence of physiological plasminogen and uPA concentrations. Thus, the uPA-plasmin system may represent a physiological mechanism for the control of gelatinase activity.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-1311314, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-1317162, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-1322794, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-1339240, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-1394213, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-1397099, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-1463464, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-1480033, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-1537850, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-1645711, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-1689240, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-1783204, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-1829461, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-1846313, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-1849141, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-1911847, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-2154522, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-2156852, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-2162246, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-2169338, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-2169614, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-2456098, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-2503527, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-2536363, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-2551898, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-2554304, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-2834383, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-2991901, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-3011276, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-3022933, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-3023400, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-3031025, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-3143380, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-3745161, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-3880760, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-6339645, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-66627, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-7188842, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-7397689, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-7540230, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-7615163, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-7657516, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-7657517, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-7657518, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-7708715, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-7728753, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-7772054, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-7822314, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-7890717, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-8015608, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-8183903, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-8240832, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-8253870, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-8280471, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-8314771, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-8391388, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-8400293, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-8419965, http://linkedlifedata.com/resource/pubmed/commentcorrection/9171346-8646777
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Collagenases, http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Precursors, http://linkedlifedata.com/resource/pubmed/chemical/Fibrinolysin, http://linkedlifedata.com/resource/pubmed/chemical/Gelatinases, http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 2, http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 9, http://linkedlifedata.com/resource/pubmed/chemical/Metalloendopeptidases, http://linkedlifedata.com/resource/pubmed/chemical/PLAUR protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Plasminogen Activators, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Urokinase Plasminogen..., http://linkedlifedata.com/resource/pubmed/chemical/Urokinase-Type Plasminogen Activator, http://linkedlifedata.com/resource/pubmed/chemical/progelatinase
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0261-4189
pubmed:author
pubmed:issnType
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