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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1997-6-12
|
| pubmed:abstractText |
To determine the influence of HIV-1 replication on immunologic decline and clinical outcome, we quantified the HIV-1 plasma viral load in 20 patients at different times over a mean period of 10.8 months. Quantitation was performed by branched DNA signal amplification (bDNA) and p24 antigenemia. Immunologic status was assessed through beta 2-microglobulin and CD4+ cell count determinations. CD4+ cell decline was expressed as a slope of the regression line constructed by the logarithms of CD4+ cell count observations. Mean values of plasma viral load were correlated with CD4+ cell decline and mean beta 2-microglobulin levels. Significant correlation was observed between plasma viral load quantified by the bDNA technique and CD4+ cell decline. No significant correlation was observed between plasma viral load quantified by p24 antigenemia and CD4+ cell decline. A significant correlation was observed between plasma viral load and beta 2-microglobulin levels. Immunologic decline was better predicted from HIV-1 RNA levels than from the CD4+ cell count. Significantly higher plasma viral load was observed in patients who had clinical progression of HIV-1 infection. Thus, HIV-1 plasma viral load quantified by a highly reliable technique such as bDNA showed that the immunologic decline is closely related to HIV-1 RNA replication.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-HIV Agents,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Didanosine,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Core Protein p24,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Stavudine,
http://linkedlifedata.com/resource/pubmed/chemical/Zalcitabine,
http://linkedlifedata.com/resource/pubmed/chemical/Zidovudine,
http://linkedlifedata.com/resource/pubmed/chemical/beta 2-Microglobulin
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
1077-9450
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
14
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
408-14
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9170414-Anti-HIV Agents,
pubmed-meshheading:9170414-CD4 Lymphocyte Count,
pubmed-meshheading:9170414-DNA, Viral,
pubmed-meshheading:9170414-Didanosine,
pubmed-meshheading:9170414-Disease Progression,
pubmed-meshheading:9170414-Drug Therapy, Combination,
pubmed-meshheading:9170414-HIV Core Protein p24,
pubmed-meshheading:9170414-HIV Infections,
pubmed-meshheading:9170414-HIV-1,
pubmed-meshheading:9170414-Humans,
pubmed-meshheading:9170414-Longitudinal Studies,
pubmed-meshheading:9170414-RNA, Viral,
pubmed-meshheading:9170414-Stavudine,
pubmed-meshheading:9170414-Viral Load,
pubmed-meshheading:9170414-Viremia,
pubmed-meshheading:9170414-Virus Replication,
pubmed-meshheading:9170414-Zalcitabine,
pubmed-meshheading:9170414-Zidovudine,
pubmed-meshheading:9170414-beta 2-Microglobulin
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Correlation between plasma HIV-1 RNA levels and the rate of immunologic decline.
|
| pubmed:affiliation |
Department of Biomedicine, University of Pisa, Italy.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study
|