Linked Life Data

9170412

Source:http://linkedlifedata.com/resource/pubmed/id/9170412

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1997-6-12
pubmed:abstractText
We present a model of the dynamics of CD4 and CD8 T-cell subsets in the thymus and peripheral blood and use it to study the blind homeostasis hypothesis, which states that the total T-cell population in the periphery is subject to regulation rather than regulation of the CD4 or CD8 subsets individually. Our model reconstructs experimental observations by Adleman and Wofsy on the effects of CD4+ T-cell depletion in mice. Our results point to the importance of the thymus in recovery from CD4+ T-cell depletion and particularly to the need to hypothesize an intrathymic feedback regulation of T-cell production exerted by CD4+ T cells. Our results support the blind homeostasis hypothesis for regulation of the peripheral blood levels of CD4+ and CD8- T cells.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1077-9450
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
387-98
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Blind T-cell homeostasis and the CD4/CD8 ratio in the thymus and peripheral blood.
pubmed:affiliation
Department of Molecular Biology, Princeton University, New Jersey, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't