Linked Life Data

9169546

Source:http://linkedlifedata.com/resource/pubmed/id/9169546

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1997-6-30
pubmed:abstractText
A corticotropin release-inhibiting factor (CRIF) in brain has been postulated for several decades, based on increased plasma levels of ACTH and corticosterone after hypothalamic-pituitary disconnection. Recent in vitro studies indicate that prepro-TRH178-199 may function as an endogenous CRIF, prompting us to examine stress-related neuroendocrine and behavioral responses after in vivo administration to the adult male rat. Animals that were administered prepro-TRH178-199 intravenously 5 min before restraint stress exhibited a significant attenuation of stress-induced elevations of ACTH, corticosterone, and prolactin, as compared with controls infused with vehicle, whereas thyroid-stimulating hormone (TSH) secretion was not changed. In behavioral studies of stress responsiveness, either the vehicle or prepro-TRH178-199 was administered intracerebroventricularly (ICV) 5 min before testing. In the open field, prepro-TRH178-199 significantly increased grooming, locomotor activity, rearing, and sniffing behaviors. In the light/dark box, it significantly increased the time animals spent in the light compartment and increased the number of crossings between the light/dark compartments. In the plus maze, the peptide significantly increased the amount of time animals spent in the open arms. The same dose of peptide, administered ICV, had no effect on peripheral hormone release in response to restraint stress. Overall, these results support a role for prepro-TRH178-199 in the inhibition of the neuroendocrine responses to stress at the level of the pituitary and indicate that it has central modulatory influences over stress-related behaviors.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0270-6474
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4886-94
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:9169546-Adrenocorticotropic Hormone, pubmed-meshheading:9169546-Animals, pubmed-meshheading:9169546-Biological Markers, pubmed-meshheading:9169546-Cerebral Ventricles, pubmed-meshheading:9169546-Corticosterone, pubmed-meshheading:9169546-Grooming, pubmed-meshheading:9169546-Injections, Intraventricular, pubmed-meshheading:9169546-Male, pubmed-meshheading:9169546-Maze Learning, pubmed-meshheading:9169546-Motor Activity, pubmed-meshheading:9169546-Neurosecretory Systems, pubmed-meshheading:9169546-Peptide Fragments, pubmed-meshheading:9169546-Prolactin, pubmed-meshheading:9169546-Protein Precursors, pubmed-meshheading:9169546-Rats, pubmed-meshheading:9169546-Rats, Sprague-Dawley, pubmed-meshheading:9169546-Reaction Time, pubmed-meshheading:9169546-Restraint, Physical, pubmed-meshheading:9169546-Stress, Psychological, pubmed-meshheading:9169546-Thyrotropin, pubmed-meshheading:9169546-Thyrotropin-Releasing Hormone
pubmed:year
1997
pubmed:articleTitle
Inhibition of stress-induced neuroendocrine and behavioral responses in the rat by prepro-thyrotropin-releasing hormone 178-199.
pubmed:affiliation
Department of Psychology, San Diego State University, San Diego, California 92182, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't