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rdf:type |
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lifeskim:mentions |
umls-concept:C0017337,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0086418,
umls-concept:C0162415,
umls-concept:C0204727,
umls-concept:C0205409,
umls-concept:C0546910,
umls-concept:C1414669,
umls-concept:C1510464,
umls-concept:C2347858
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pubmed:issue |
3
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|
pubmed:dateCreated |
1997-7-1
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pubmed:databankReference |
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pubmed:abstractText |
The very recently found evolutionarily conserved DNA-binding domain of 100 amino acids, termed the fork head domain, emerged from a sequence comparison of the rat hepatocyte transcription factor HNF-3 alpha and the homeotic gene fork head of Drosophila. We previously isolated a new member of this family, the mesenchyme fork head-1 (MFH-1) gene, which is expressed in developing mesenchyme. Here we describe the isolation of the mouse (MFH-1) and human (FKHL14) chromosomal MFH-1 genes and the determination of the gene and protein structures of MFH-1. We found that the MFH-1 gene has no introns and that the identity of the amino acid sequences of mouse and human MFH-1 proteins is 94%. We also investigated the transcriptional activity of the mouse and human MFH-1 proteins and found that both proteins act as positive transactivators.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0888-7543
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pubmed:author |
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|
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
489-92
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9169153-Amino Acid Sequence,
pubmed-meshheading:9169153-Animals,
pubmed-meshheading:9169153-Base Sequence,
pubmed-meshheading:9169153-Cloning, Molecular,
pubmed-meshheading:9169153-Conserved Sequence,
pubmed-meshheading:9169153-DNA-Binding Proteins,
pubmed-meshheading:9169153-Drosophila,
pubmed-meshheading:9169153-Evolution, Molecular,
pubmed-meshheading:9169153-Forkhead Transcription Factors,
pubmed-meshheading:9169153-Humans,
pubmed-meshheading:9169153-Mice,
pubmed-meshheading:9169153-Molecular Sequence Data,
pubmed-meshheading:9169153-Molecular Structure,
pubmed-meshheading:9169153-Oligodeoxyribonucleotides,
pubmed-meshheading:9169153-Rats,
pubmed-meshheading:9169153-Sequence Homology, Amino Acid,
pubmed-meshheading:9169153-Trans-Activators,
pubmed-meshheading:9169153-Transcription Factors
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pubmed:year |
1997
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pubmed:articleTitle |
Isolation of the mouse (MFH-1) and human (FKHL 14) mesenchyme fork head-1 genes reveals conservation of their gene and protein structures.
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pubmed:affiliation |
Department of Biochemistry, Akita University School of Medicine, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
