Linked Life Data

9166918

Source:http://linkedlifedata.com/resource/pubmed/id/9166918

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1997-7-24
pubmed:abstractText
The nucleus basalis of Meynert (nbM, substantia innominata) in the basal forebrain provides a single major source of cholinergic innervation for the entire cerebral cortex. We tested the effects of nbM lesions on rabbit P300-like potentials. The P300-like event-related potential (ERP) was recorded in 14 female adult white rabbits using a conventional auditory oddball paradigm. The probability of occurrence for the 2-kHz and 1-kHz stimulus tones was 90% (frequent) and 10% (rare), respectively. The nbM was destroyed bilaterally in seven rabbits referred to as the nbM (+) group. In the other seven rabbits [nbM (-) group], putamen nuclei (n=6) or amygdaloid nuclei (n=1) were destroyed bilaterally. The evoked responses were recorded before and 1 week after the destruction. In the nbM (+) group, P300 amplitude to rare stimuli significantly decreased after the lesion. In the nbM (-) group, no component of ERPs showed changes after the lesions. These results indicate that the nbM might be involved in the generation of the rabbit P300.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0014-4819
pubmed:author
pubmed:issnType
Print
pubmed:volume
114
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
288-92
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
P300-like potential disappears in rabbits with lesions in the nucleus basalis of Meynert.
pubmed:affiliation
Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Yonago, Japan.
pubmed:publicationType
Journal Article