rdf:type |
|
lifeskim:mentions |
umls-concept:C0001613,
umls-concept:C0007776,
umls-concept:C0010453,
umls-concept:C0014994,
umls-concept:C0022655,
umls-concept:C0027882,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0220839,
umls-concept:C0229671,
umls-concept:C0230445,
umls-concept:C0521457,
umls-concept:C0596402,
umls-concept:C1555707,
umls-concept:C1705851,
umls-concept:C2752151,
umls-concept:C2828366
|
pubmed:issue |
4
|
pubmed:dateCreated |
1997-8-27
|
pubmed:abstractText |
The effects of an ether extract of fetal calf serum (EE-FCS) on glutamate-induced cytotoxicity were examined using primary cultures of rat cortical neurons. The simultaneous addition of EE-FCS and glutamate reduced glutamate cytotoxicity in a concentration-dependent manner. EE-FCS also reduced the cytotoxicity induced by S-nitrosocysteine, a nitric oxide (NO) donor. The findings indicate that EE-FCS contains lipid-soluble, non-peptide substances with neuroprotective actions against NO-mediated glutamate neurotoxicity.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
0021-5198
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
73
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
371-4
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:9165377-Animals,
pubmed-meshheading:9165377-Cattle,
pubmed-meshheading:9165377-Cells, Cultured,
pubmed-meshheading:9165377-Cerebral Cortex,
pubmed-meshheading:9165377-Corpus Striatum,
pubmed-meshheading:9165377-Cysteine,
pubmed-meshheading:9165377-Dose-Response Relationship, Drug,
pubmed-meshheading:9165377-Ethers,
pubmed-meshheading:9165377-Fetal Blood,
pubmed-meshheading:9165377-Glutamic Acid,
pubmed-meshheading:9165377-Neurons,
pubmed-meshheading:9165377-Nitric Oxide,
pubmed-meshheading:9165377-Rats,
pubmed-meshheading:9165377-S-Nitrosothiols
|
pubmed:year |
1997
|
pubmed:articleTitle |
Ether extract of fetal calf serum protects cultured rat cortical neurons against glutamate cytotoxicity.
|
pubmed:affiliation |
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|