Linked Life Data

9164992

Source:http://linkedlifedata.com/resource/pubmed/id/9164992

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1997-6-16
pubmed:abstractText
Earlier studies suggest that butyrate has colonic differentiating and nutritional effects and that acarbose increases butyrate production. To determine the effects of acarbose on colonic fermentation, subjects were given 50-200 mg acarbose or placebo (cornstarch), three times per day, with meals in a double-blind crossover study. Fecal concentrations of starch and starch-fermenting bacteria were measured and fecal fermentation products determined after incubation of fecal suspensions with and without added substrate for 6 and 24 h. Substrate additions were cornstarch, cornstarch plus acarbose and potato starch. Dietary starch consumption was similar during acarbose and placebo treatment periods, but fecal starch concentrations were found to be significantly greater with acarbose treatment. Ratios of starch-fermenting to total anaerobic bacteria were also significantly greater with acarbose treatment. Butyrate in feces, measured either as concentration or as percentage of total short-chain fatty acids, was significantly greater with acarbose treatment than with placebo treatment. Butyrate ranged from 22.3 to 27.5 mol/100 mol for the 50-200 mg, three times per day doses of acarbose compared with 18.3-19.3 mol/100 mol for the comparable placebo periods. The propionate in fecal total short-chain fatty acids was significantly less with acarbose treatment (10.7-12.1 mol/100 mol) than with placebo treatment (13.7-14.2 mol/100 mol). Butyrate production was significantly greater in fermentations in samples collected during acarbose treatment, whereas production of acetate and propionate was significantly less. Fermentation decreased when acarbose was added directly to cornstarch fermentations. Acarbose effectively augmented colonic butyrate production by several mechanisms; it reduced starch absorption, expanded concentrations of starch-fermenting and butyrate-producing bacteria and inhibited starch use by acetate- and propionate-producing bacteria.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-3166
pubmed:author
pubmed:issnType
Print
pubmed:volume
127
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
717-23
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:9164992-Acarbose, pubmed-meshheading:9164992-Adult, pubmed-meshheading:9164992-Butyrates, pubmed-meshheading:9164992-Chromatography, Gas, pubmed-meshheading:9164992-Colon, pubmed-meshheading:9164992-Dietary Carbohydrates, pubmed-meshheading:9164992-Dose-Response Relationship, Drug, pubmed-meshheading:9164992-Double-Blind Method, pubmed-meshheading:9164992-Fatty Acids, Volatile, pubmed-meshheading:9164992-Feces, pubmed-meshheading:9164992-Female, pubmed-meshheading:9164992-Fermentation, pubmed-meshheading:9164992-Humans, pubmed-meshheading:9164992-Hydrogen, pubmed-meshheading:9164992-Hypoglycemic Agents, pubmed-meshheading:9164992-Male, pubmed-meshheading:9164992-Methane, pubmed-meshheading:9164992-Middle Aged, pubmed-meshheading:9164992-Starch, pubmed-meshheading:9164992-Trisaccharides
pubmed:year
1997
pubmed:articleTitle
Acarbose enhances human colonic butyrate production.
pubmed:affiliation
Department of Medicine, The Mary Imogene Bassett Hospital, Cooperstown, NY 13326, USA.
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, U.S. Gov't, P.H.S., Randomized Controlled Trial, Research Support, Non-U.S. Gov't