Linked Life Data

9164921

Source:http://linkedlifedata.com/resource/pubmed/id/9164921

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1997-6-19
pubmed:abstractText
Engagement of killer cell inhibitory receptors (KIRs) with their MHC class I ligands inhibits T and NK lymphocyte activation. In humans, killer cell activatory receptors (KARs) are highly homologous to KIRs, interact with an identical set of MHC class I molecules, and are encoded by individual genes belonging to the Ig-like superfamily. In contrast to KIRs, engagement of KARs leads to T and NK cell activation. We identified a set of disulfide-linked dimers selectively associated with KARs. KAR-associated polypeptides (KARAPs) are phosphorylated on tyrosine and serine residues. Reconstitution of KAR cell surface expression in the absence of KARAPs correlates with the failure of KAR to transduce any detectable activation signals. These results indicate that KARs are included in a multimeric complex with phosphorylated KARAPs and define a novel set of polypeptides that are likely to be involved in the control of lymphocyte activation upon MHC class I recognition.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
158
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5083-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Human killer cell activatory receptors for MHC class I molecules are included in a multimeric complex expressed by natural killer cells.
pubmed:affiliation
Center for Immunology, INSERM/CNRS of Marseille-Luminy, Marseille, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't