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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
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|
pubmed:dateCreated |
1997-6-16
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|
pubmed:abstractText |
We performed a pharmacologic investigation of paclitaxel (PTX) infused over 3 hours and bolus doxorubicin (DOX) to assess the role of sequence, interval between drugs, and duration of doxorubicin infusion on paclitaxel and anthracycline plasma disposition. We also explored possible mechanisms of pharmacokinetic interference involving the physiologic role of the multidrug resistance phenotype in anthracycline and taxane biliary excretion.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
May
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pubmed:issn |
0732-183X
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
15
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
1906-15
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|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9164201-Adult,
pubmed-meshheading:9164201-Aged,
pubmed-meshheading:9164201-Antibiotics, Antineoplastic,
pubmed-meshheading:9164201-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:9164201-Breast Neoplasms,
pubmed-meshheading:9164201-Chromatography, High Pressure Liquid,
pubmed-meshheading:9164201-Doxorubicin,
pubmed-meshheading:9164201-Drug Administration Schedule,
pubmed-meshheading:9164201-Drug Interactions,
pubmed-meshheading:9164201-Female,
pubmed-meshheading:9164201-Humans,
pubmed-meshheading:9164201-Middle Aged,
pubmed-meshheading:9164201-Paclitaxel
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|
pubmed:year |
1997
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|
pubmed:articleTitle |
Human pharmacokinetic characterization and in vitro study of the interaction between doxorubicin and paclitaxel in patients with breast cancer.
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|
pubmed:affiliation |
Division of Medical Oncology, Istituto Nazionale Tumori, Milan, Italy. GIANNI@istitutotumori.mi.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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