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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1997-7-8
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pubmed:abstractText |
A prospective analysis of 38 cases of bovine lymphoma was performed. Thirty-five of the lymphomas were considered enzootic because of serologic or molecular biologic association with the bovine leukemia virus (BLV). The three remaining cases were in cattle < 1 year of age and were not associated with BLV and hence were considered sporadic lymphomas. Utilizing the national cancer Institute Working Formulation for the morphologic classification of human non-Hodgkin's lymphoma, 54.3% (19/35) of the enzootic lymphomas were classified as the diffuse large cleaved cell type. The cells of the 35 enzootic lymphomas expressed a consistent immunophenotype represented by MHCII+, gamma-heavy chain+, and lambda-light chain+; this constellation of markers indicated a mature B-cell phenotype. The three sporadic lymphomas failed to express MHCII antigen despite the presence of other B-cell antigens. There was no correlation between morphologic cell type and immunophenotype in these bovine lymphomas.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0300-9858
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
222-5
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:9163878-Animals,
pubmed-meshheading:9163878-Cattle,
pubmed-meshheading:9163878-Enzootic Bovine Leukosis,
pubmed-meshheading:9163878-Female,
pubmed-meshheading:9163878-Immunophenotyping,
pubmed-meshheading:9163878-Leukemia Virus, Bovine,
pubmed-meshheading:9163878-Lymphoma, B-Cell,
pubmed-meshheading:9163878-Lymphoma, Large B-Cell, Diffuse,
pubmed-meshheading:9163878-Lymphoma, Non-Hodgkin,
pubmed-meshheading:9163878-Prospective Studies
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pubmed:year |
1997
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pubmed:articleTitle |
The immunophenotypic characterization of bovine lymphomas.
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pubmed:affiliation |
Department of Pathobiology, University of Guelph, ON, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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