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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1997-6-12
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pubmed:abstractText |
The modifying effect of dietary administration of a xanthine oxidase inhibitor 1'-acetoxychavicol acetate (ACA) present in an edible plant Languas galanga in Thailand on the development of azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF) was investigated in rats. Male F344 rats were given s.c. injections of AOM (15 mg/kg body wt) once a week for 3 weeks to induce colonic ACF. They were fed the diets containing 100 or 200 ppm ACA for 5 weeks, starting 1 week before the first dosing of AOM. At the termination of the study (week 5), AOM induced 118 +/- 28 ACF/colon. Dietary administration of ACA caused significant reduction in the frequency of ACF (41% inhibition by 100 ppm ACA feeding and 37% inhibition by 200 ppm ACA feeding, P<0.01). Such inhibition might be associated with suppression of the proliferation biomarkers' expression such as ornithine decarboxylase activity in the colonic mucosa, number of silver-stained nucleolar organizer regions' protein in the colonic mucosal cell nuclei and blood polyamine content. These results indicate that ACA could inhibit the development of AOM-induced ACF through its suppression of cell proliferation in the colonic mucosa and ACA might be a possible chemopreventive agent against colon tumourigenesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0143-3334
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1113-8
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9163704-Animals,
pubmed-meshheading:9163704-Antineoplastic Agents,
pubmed-meshheading:9163704-Azoxymethane,
pubmed-meshheading:9163704-Benzyl Alcohols,
pubmed-meshheading:9163704-Body Weight,
pubmed-meshheading:9163704-Cell Division,
pubmed-meshheading:9163704-Colon,
pubmed-meshheading:9163704-Colonic Diseases,
pubmed-meshheading:9163704-Enzyme Inhibitors,
pubmed-meshheading:9163704-Intestinal Mucosa,
pubmed-meshheading:9163704-Liver,
pubmed-meshheading:9163704-Male,
pubmed-meshheading:9163704-Organ Size,
pubmed-meshheading:9163704-Ornithine Decarboxylase,
pubmed-meshheading:9163704-Polyamines,
pubmed-meshheading:9163704-Precancerous Conditions,
pubmed-meshheading:9163704-Rats,
pubmed-meshheading:9163704-Rats, Inbred F344,
pubmed-meshheading:9163704-Terpenes,
pubmed-meshheading:9163704-Xanthine Oxidase
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pubmed:year |
1997
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pubmed:articleTitle |
A xanthine oxidase inhibitor 1'-acetoxychavicol acetate inhibits azoxymethane-induced colonic aberrant crypt foci in rats.
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pubmed:affiliation |
First Department of Pathology, Gifu University School of Medicine, Tsukasa-machi, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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