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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1997-7-16
|
| pubmed:abstractText |
Glucagon-like peptide-1 (GLP-1), structurally similar to glucagon, is synthesized from a larger precursor, preproglucagon, and has been postulated to be a novel incretin. Recently, it was reported that central administration of GLP-1 decreased food intake in rats. The amino acid sequences of GLP-1 are identical in all mammals, and chicken GLP-1 exhibits a high homology with mammalian GLP-1. The aim of this study was to elucidate whether central injection of mammalian or chicken GLP-1 inhibits food intake in the chick, and to compare their effects. Intracerebroventricular administration of mammalian and chicken GLP-1 strongly inhibited food intake of chicks. However, the suppressive effect of both GLP-1 on food intake was similar. These results show that GLP-1 with a variety of amino acid sequences may be the most potent inhibitor of food intake in the chicken.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0006-8993
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
25
|
| pubmed:volume |
755
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
167-9
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9163555-Amino Acid Sequence,
pubmed-meshheading:9163555-Analysis of Variance,
pubmed-meshheading:9163555-Animals,
pubmed-meshheading:9163555-Animals, Newborn,
pubmed-meshheading:9163555-Chickens,
pubmed-meshheading:9163555-Dose-Response Relationship, Drug,
pubmed-meshheading:9163555-Drug Evaluation, Preclinical,
pubmed-meshheading:9163555-Feeding Behavior,
pubmed-meshheading:9163555-Female,
pubmed-meshheading:9163555-Glucagon,
pubmed-meshheading:9163555-Glucagon-Like Peptide 1,
pubmed-meshheading:9163555-Injections, Intraventricular,
pubmed-meshheading:9163555-Male,
pubmed-meshheading:9163555-Mammals,
pubmed-meshheading:9163555-Molecular Sequence Data,
pubmed-meshheading:9163555-Peptides,
pubmed-meshheading:9163555-Sequence Homology, Amino Acid,
pubmed-meshheading:9163555-Species Specificity
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Intracerebroventricular injection of mammalian and chicken glucagon-like peptide-1 inhibits food intake of the neonatal chick.
|
| pubmed:affiliation |
Laboratory of Animal Nutrition, School of Agricultural Sciences, Nagoya University, Japan. j46117a@nucc.cc.nagoya-u.ac.jp
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|