Linked Life Data

9161096

Source:http://linkedlifedata.com/resource/pubmed/id/9161096

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1997-7-24
pubmed:abstractText
Numerous clinical reports documented that in some patients vincristine (VCR) may cause a risk for life (stridor) and painful symptoms of acute intoxication. The present study was undertaken to examine ultrastructural changes in the sciatic nerve of rabbits following acute vincristine intoxication. Our results show, that in a few hours, some axons of this nerve may undergo degeneration and atrophy. These changes were initially followed by the cleavage of adaxonal myelin sheets, that spontaneously formed concentric scrolls and tangled threads. Finally, myelin sheath collapsed around the atrophied axon. The results provide evidence that acute VCR intoxication primarily affects the axons. Myelin changes are caused by the loss of supportive role of atrophied axon for the myelin sheath. The effect of intoxicated Schwann cells on the myelin in acute VCR intoxication is not clear and requires further study.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1641-4640
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
18-23
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Ultrastructure of myelinated fibers of sciatic nerve in acute vincristine intoxication.
pubmed:affiliation
Laboratory of Developmental Neuropathology, Polish Academy of Sciences, Warszawa.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't