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pubmed:abstractText |
Heterologous surface display on Gram-negative bacterial was first described a decade ago and is now an active research area. More recently, strategies for surface display on Gram-positive bacterial have also been devised and these carry some inherent advantages. Bacterial surface display has found a range of applications in the expression of various antigenic determinants, heterologous enzymes, single-chain antibodies, polyhistidyl tags and even entire peptide libraries. This article explains the basis of bacterial surface display and discusses current uses and possible future trends of this emerging technology.
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