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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1997-6-10
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pubmed:abstractText |
Vascular endothelial growth factor (VEGF) increased the level of ETS1 mRNA in human umbilical vein endothelial cells (HUVEC) and human lung microvascular endothelial cells (HMVEC-L) over 5-fold. Protein levels were shown to increase concordantly. VEGF was also found to stimulate the invasiveness of endothelial cells as measured by migration through Matrigel- or gelatin-coated membranes. The VEGF-induced invasiveness was inhibited by ETS1 antisense oligonucleotides but not by a sense control. In addition, the ETS1 antisense oligonucleotides reduced the levels of ETS1 and urokinase-type plasminogen activator mRNAs. The antisense oligonucleotides directed against the ETS1 gene thus altered a cellular property of endothelial cells that is correlated with the ability of the cells to migrate through basement membranes. Together, these observations demonstrate a direct role for the ETS1 gene in angiogenesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Collagen,
http://linkedlifedata.com/resource/pubmed/chemical/Drug Combinations,
http://linkedlifedata.com/resource/pubmed/chemical/ETS1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Endothelial Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Gelatin,
http://linkedlifedata.com/resource/pubmed/chemical/Laminin,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphokines,
http://linkedlifedata.com/resource/pubmed/chemical/Oligonucleotides, Antisense,
http://linkedlifedata.com/resource/pubmed/chemical/Proteoglycans,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Protein c-ets-1,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-ets,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Tetradecanoylphorbol Acetate,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Urokinase-Type Plasminogen Activator,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/matrigel
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0008-5472
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
57
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2013-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9157999-Cell Division,
pubmed-meshheading:9157999-Cell Movement,
pubmed-meshheading:9157999-Cells, Cultured,
pubmed-meshheading:9157999-Collagen,
pubmed-meshheading:9157999-Drug Combinations,
pubmed-meshheading:9157999-Endothelial Growth Factors,
pubmed-meshheading:9157999-Endothelium, Vascular,
pubmed-meshheading:9157999-Gelatin,
pubmed-meshheading:9157999-Gene Expression,
pubmed-meshheading:9157999-Gene Expression Regulation,
pubmed-meshheading:9157999-Humans,
pubmed-meshheading:9157999-Laminin,
pubmed-meshheading:9157999-Lymphokines,
pubmed-meshheading:9157999-Membranes,
pubmed-meshheading:9157999-Oligonucleotides, Antisense,
pubmed-meshheading:9157999-Proteoglycans,
pubmed-meshheading:9157999-Proto-Oncogene Protein c-ets-1,
pubmed-meshheading:9157999-Proto-Oncogene Proteins,
pubmed-meshheading:9157999-Proto-Oncogene Proteins c-ets,
pubmed-meshheading:9157999-RNA, Messenger,
pubmed-meshheading:9157999-Stimulation, Chemical,
pubmed-meshheading:9157999-Tetradecanoylphorbol Acetate,
pubmed-meshheading:9157999-Transcription Factors,
pubmed-meshheading:9157999-Urokinase-Type Plasminogen Activator,
pubmed-meshheading:9157999-Vascular Endothelial Growth Factor A,
pubmed-meshheading:9157999-Vascular Endothelial Growth Factors
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pubmed:year |
1997
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pubmed:articleTitle |
Inhibition of vascular endothelial growth factor-induced endothelial cell migration by ETS1 antisense oligonucleotides.
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pubmed:affiliation |
Scientific Applications International Corporation, National Cancer Institute-Frederick Cancer Research and Development Center, Maryland 21702-1201, USA.
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pubmed:publicationType |
Journal Article
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