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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1997-5-22
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pubmed:abstractText |
As part of a search for novel inhibitors of endothelin converting enzyme (ECE), the MeOH-CH2Cl2 extract of the roots of Dalea filiciformis was shown to be active. Bioassay-guided fractionation of the extract yielded a novel phytoalexin, daleformis (1), whose structure was determined by interpretation of spectral data and X-ray analysis. Daleformis (1) inhibited ECE with an IC50 of 9 microM.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0163-3864
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
306-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9157193-Acetylation,
pubmed-meshheading:9157193-Aspartic Acid Endopeptidases,
pubmed-meshheading:9157193-Benzofurans,
pubmed-meshheading:9157193-Benzopyrans,
pubmed-meshheading:9157193-Chromatography, Thin Layer,
pubmed-meshheading:9157193-Crystallography, X-Ray,
pubmed-meshheading:9157193-Enzyme Inhibitors,
pubmed-meshheading:9157193-Metalloendopeptidases,
pubmed-meshheading:9157193-Molecular Conformation,
pubmed-meshheading:9157193-Plant Roots,
pubmed-meshheading:9157193-Plants, Medicinal,
pubmed-meshheading:9157193-Spectrophotometry, Infrared
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pubmed:year |
1997
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pubmed:articleTitle |
Daleformis, a new phytoalexin from the roots fo Dalea filiciformis: an inhibitor of endothelin converting enzyme.
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pubmed:affiliation |
Department of Biomolecular Discovery and Analytical Sciences, SmithKline Beecham Pharmaceuticals, Research and Development, King of Prussia, Pennsylvania 19406-0939.
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pubmed:publicationType |
Journal Article
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