Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1997-6-27
pubmed:databankReference
pubmed:abstractText
In the phytopathogenic fungus Ustilago maydis, cell fusion is governed by a pheromone signalling system. The pheromone receptors belong to the seven transmembrane class that are coupled to heterotrimeric G proteins. We have isolated four genes (gpa1 to gpa4) encoding alpha subunits of G proteins. Gpa1, Gpa2 and Gpa3 have homologues in other fungal species, while Gpa4 is novel. Null mutants in individual genes were viable and only disruption of gpa3 caused a discernible phenotype. gpa3 mutant strains were unable to respond to pheromone and thus were mating-deficient. A constitutively active allele of gpa3 (gpa3(Q206L)) was generated by site-directed mutagenesis. Haploid strains harbouring gpa3(Q206L) were able to mate without pheromone stimulation, indicating that Gpa3 plays an active role in transmission of the pheromone signal. Surprisingly, Gpa3 is also required for pathogenic development, although pheromone signalling is not essential for this process.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9155019-1310895, http://linkedlifedata.com/resource/pubmed/commentcorrection/9155019-1340462, http://linkedlifedata.com/resource/pubmed/commentcorrection/9155019-1652922, http://linkedlifedata.com/resource/pubmed/commentcorrection/9155019-1697681, http://linkedlifedata.com/resource/pubmed/commentcorrection/9155019-1851251, http://linkedlifedata.com/resource/pubmed/commentcorrection/9155019-1879000, http://linkedlifedata.com/resource/pubmed/commentcorrection/9155019-1909108, http://linkedlifedata.com/resource/pubmed/commentcorrection/9155019-2549064, http://linkedlifedata.com/resource/pubmed/commentcorrection/9155019-2830616, http://linkedlifedata.com/resource/pubmed/commentcorrection/9155019-3113739, http://linkedlifedata.com/resource/pubmed/commentcorrection/9155019-5731752, http://linkedlifedata.com/resource/pubmed/commentcorrection/9155019-7816838, http://linkedlifedata.com/resource/pubmed/commentcorrection/9155019-7834739, http://linkedlifedata.com/resource/pubmed/commentcorrection/9155019-7886455, http://linkedlifedata.com/resource/pubmed/commentcorrection/9155019-7926737, http://linkedlifedata.com/resource/pubmed/commentcorrection/9155019-7984417, http://linkedlifedata.com/resource/pubmed/commentcorrection/9155019-8157001, http://linkedlifedata.com/resource/pubmed/commentcorrection/9155019-8590631, http://linkedlifedata.com/resource/pubmed/commentcorrection/9155019-8602158, http://linkedlifedata.com/resource/pubmed/commentcorrection/9155019-8612267, http://linkedlifedata.com/resource/pubmed/commentcorrection/9155019-8612587, http://linkedlifedata.com/resource/pubmed/commentcorrection/9155019-8628244, http://linkedlifedata.com/resource/pubmed/commentcorrection/9155019-8791425, http://linkedlifedata.com/resource/pubmed/commentcorrection/9155019-8825473, http://linkedlifedata.com/resource/pubmed/commentcorrection/9155019-8914511
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent..., http://linkedlifedata.com/resource/pubmed/chemical/Fungal Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Fuz7 protein, Ustilago maydis, http://linkedlifedata.com/resource/pubmed/chemical/GPA1 protein, S cerevisiae, http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Protein alpha Subunits, http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Protein alpha..., http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Heterotrimeric GTP-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase..., http://linkedlifedata.com/resource/pubmed/chemical/Pheromones, http://linkedlifedata.com/resource/pubmed/chemical/Saccharomyces cerevisiae Proteins
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0261-4189
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1934-42
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:9155019-Calcium-Calmodulin-Dependent Protein Kinases, pubmed-meshheading:9155019-Cloning, Molecular, pubmed-meshheading:9155019-Crosses, Genetic, pubmed-meshheading:9155019-Fungal Proteins, pubmed-meshheading:9155019-GTP-Binding Protein alpha Subunits, pubmed-meshheading:9155019-GTP-Binding Protein alpha Subunits, Gq-G11, pubmed-meshheading:9155019-GTP-Binding Proteins, pubmed-meshheading:9155019-Genes, Fungal, pubmed-meshheading:9155019-Heterotrimeric GTP-Binding Proteins, pubmed-meshheading:9155019-Mitogen-Activated Protein Kinase Kinases, pubmed-meshheading:9155019-Pheromones, pubmed-meshheading:9155019-Saccharomyces cerevisiae Proteins, pubmed-meshheading:9155019-Sequence Analysis, DNA, pubmed-meshheading:9155019-Sequence Homology, Amino Acid, pubmed-meshheading:9155019-Signal Transduction, pubmed-meshheading:9155019-Ustilago
pubmed:year
1997
pubmed:articleTitle
G proteins in Ustilago maydis: transmission of multiple signals?
pubmed:affiliation
Institut für Genetik und Mikrobiologie der Universität München, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't