Linked Life Data

9155006

Source:http://linkedlifedata.com/resource/pubmed/id/9155006

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
21
pubmed:dateCreated
1997-6-9
pubmed:abstractText
The effects of phorbol 12,13 dibutyrate (PDBu) on the isometric tone of gall bladder strips isolated from guinea pig were investigated. PDBu caused the development of a contractile force at concentrations of 5 nM to 1 microM, which was abolished by staurosporine (30 nM). The contraction was completely inhibited in Ca2+-free solution and by pretreatment with verapamil (1 microM) or nifedipine (1 microM). A lower concentration of PDBu (1 nM) potentiated the contractile response to KCl: it increased the sensitivity, but not the reactivity of KCl-induced contraction. Ca2+-induced contraction in the solution with 15 mM KCl was significantly augmented by the pretreatment with 1 nM PDBu. However, PDBu (1 nM) affected neither Ca2+-induced contraction in the presence of Ca2+ ionophore A23187 (0.7 microM) and verapamil (1 microM) nor Ba2+-induced contraction in the Ca2+-free solution. These results suggest that activation of protein kinase C induces completely extracellular Ca2+-dependent contraction by activating the voltage-dependent Ca2+ channels in gall bladder of guinea pig.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0024-3205
pubmed:author
pubmed:issnType
Print
pubmed:volume
60
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
PL 311-6
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Extracellular Ca2+-dependent contractile action of phorbol 12,13-dibutyrate on gall bladder from guinea pig.
pubmed:affiliation
Department of Hygiene, Hyogo College of Medicine, Nishinomiya, Japan.
pubmed:publicationType
Journal Article