Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1997-6-17
pubmed:abstractText
The present study was designed to test the hypothesis that estrogen receptors (ER) in the blood vessel wall play a role in the modulation of the release of endothelium-derived nitric oxide (EDNO). Both basal and stimulated release of EDNO were determined in aortic rings isolated from female and male wild-type and male homozygous estrogen receptor knock-out (ERKO) mice. 125I-17beta-estradiol binding in aortic tissue showed significantly more high affinity cytosolic- nuclear-binding sites in male compared with female wildtype mice. Estrogen receptor transcripts were present in the aorta of male wild-type mice, but they were absent in male ERKO animals. Basal release of EDNO (determined by endothelium-dependent contraction caused by NG-nitro-arginine) was significantly higher in aorta of wild-type male mice compared with wild-type female mice, and significantly lower in the aorta of male ERKO compared with male wild-type mice. Acetylcholine-induced endothelium-dependent relaxation was similar in all groups studied. No difference was observed in the activity of calcium-dependent nitric oxide synthase in homogenates of lungs and brain taken from male wild-type and ERKO mice. These studies show a significant association between the number of estrogen receptors and basal release of EDNO in the aorta of mice, and suggest that decreased vascular estrogen receptor number may represent a novel risk factor for cardiovascular diseases.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-1454805, http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-1530046, http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-1797335, http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-1852778, http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-1870648, http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-2244855, http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-225399, http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-2331772, http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-2440339, http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-2573074, http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-3121846, http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-3402394, http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-3422428, http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-3502252, http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-3606719, http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-3757281, http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-3874557, http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-436778, http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-6253831, http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-6281310, http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-684408, http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-7200404, http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-7522401, http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-7523767, http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-7533729, http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-7545787, http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-7682524, http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-7721443, http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-7810731, http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-7978718, http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-7985022, http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-8149515, http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-8248223, http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-8584021, http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-8620594, http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-862138
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0021-9738
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
99
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2429-37
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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