rdf:type |
|
lifeskim:mentions |
umls-concept:C0003483,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0028128,
umls-concept:C0033268,
umls-concept:C0034804,
umls-concept:C0036866,
umls-concept:C0332453,
umls-concept:C1280500,
umls-concept:C1335671,
umls-concept:C1801960
|
pubmed:issue |
10
|
pubmed:dateCreated |
1997-6-17
|
pubmed:abstractText |
The present study was designed to test the hypothesis that estrogen receptors (ER) in the blood vessel wall play a role in the modulation of the release of endothelium-derived nitric oxide (EDNO). Both basal and stimulated release of EDNO were determined in aortic rings isolated from female and male wild-type and male homozygous estrogen receptor knock-out (ERKO) mice. 125I-17beta-estradiol binding in aortic tissue showed significantly more high affinity cytosolic- nuclear-binding sites in male compared with female wildtype mice. Estrogen receptor transcripts were present in the aorta of male wild-type mice, but they were absent in male ERKO animals. Basal release of EDNO (determined by endothelium-dependent contraction caused by NG-nitro-arginine) was significantly higher in aorta of wild-type male mice compared with wild-type female mice, and significantly lower in the aorta of male ERKO compared with male wild-type mice. Acetylcholine-induced endothelium-dependent relaxation was similar in all groups studied. No difference was observed in the activity of calcium-dependent nitric oxide synthase in homogenates of lungs and brain taken from male wild-type and ERKO mice. These studies show a significant association between the number of estrogen receptors and basal release of EDNO in the aorta of mice, and suggest that decreased vascular estrogen receptor number may represent a novel risk factor for cardiovascular diseases.
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-1454805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-1530046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-1797335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-1852778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-1870648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-2244855,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-225399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-2331772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-2440339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-2573074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-3121846,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-3402394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-3422428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-3502252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-3606719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-3757281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-3874557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-436778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-6253831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-6281310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-684408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-7200404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-7522401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-7523767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-7533729,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-7545787,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-7682524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-7721443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-7810731,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-7978718,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-7985022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-8149515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-8248223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-8584021,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-8620594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9153286-862138
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/15-Hydroxy-11 alpha,9...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/Estradiol,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitroarginine,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin Endoperoxides...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Estrogen,
http://linkedlifedata.com/resource/pubmed/chemical/Thromboxane A2,
http://linkedlifedata.com/resource/pubmed/chemical/Vasoconstrictor Agents
|
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
0021-9738
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
15
|
pubmed:volume |
99
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
2429-37
|
pubmed:dateRevised |
2009-11-18
|
pubmed:meshHeading |
pubmed-meshheading:9153286-Animals,
pubmed-meshheading:9153286-Mice,
pubmed-meshheading:9153286-Estradiol,
pubmed-meshheading:9153286-Lung,
pubmed-meshheading:9153286-Brain,
pubmed-meshheading:9153286-Nitric Oxide,
pubmed-meshheading:9153286-Aorta,
pubmed-meshheading:9153286-Sex Characteristics,
pubmed-meshheading:9153286-Female,
pubmed-meshheading:9153286-Male,
pubmed-meshheading:9153286-Species Specificity,
pubmed-meshheading:9153286-Vasoconstrictor Agents,
pubmed-meshheading:9153286-Endothelium, Vascular,
pubmed-meshheading:9153286-Muscle Contraction,
pubmed-meshheading:9153286-Enzyme Induction,
pubmed-meshheading:9153286-Muscle, Smooth, Vascular,
pubmed-meshheading:9153286-Mice, Inbred C57BL
|