Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
21
pubmed:dateCreated
1997-7-2
pubmed:abstractText
Lysophosphatidylcholine (lyso-PC), a natural lipid generated through the action of phospholipase A2 on membrane phosphatidylcholine, has been implicated in atherogenesis and the inflammatory process. In vitro studies have established a role for lyso-PC in modulation of gene expression and other cellular responses including differentiation and proliferation. There is also evidence that lyso-PC may act as an intracellular second messenger transducing signals elicited from membrane-associated receptors. The mechanisms behind the diverse activities of lyso-PC are poorly understood. We report, in this study, that treatment of cultured cells with exogenous lyso-PC, at nontoxic concentrations, potently induced activator protein-1 (AP-1) DNA binding and transcriptional activity independent of well known AP-1 activators, protein kinase C or mitogen-activated protein kinases ERK1 and ERK2. Lyso-PC also activated the c-Jun N-terminal kinase (JNK/SAPK), a recently characterized member of the mitogen-activated protein kinase family, known to activate AP-1. The stimulated JNK and AP-1 activities probably mediate or contribute to some bioactive effects of lyso-PC.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0021-9258
pubmed:author
pubmed:issnType
Print
pubmed:day
23
pubmed:volume
272
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
13683-9
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:9153219-Animals, pubmed-meshheading:9153219-Calcium-Calmodulin-Dependent Protein Kinases, pubmed-meshheading:9153219-DNA, pubmed-meshheading:9153219-Enzyme Activation, pubmed-meshheading:9153219-Genes, jun, pubmed-meshheading:9153219-HeLa Cells, pubmed-meshheading:9153219-Humans, pubmed-meshheading:9153219-JNK Mitogen-Activated Protein Kinases, pubmed-meshheading:9153219-Lysophosphatidylcholines, pubmed-meshheading:9153219-Mitogen-Activated Protein Kinase 1, pubmed-meshheading:9153219-Mitogen-Activated Protein Kinase 3, pubmed-meshheading:9153219-Mitogen-Activated Protein Kinases, pubmed-meshheading:9153219-Protein Kinase C, pubmed-meshheading:9153219-Rats, pubmed-meshheading:9153219-Signal Transduction, pubmed-meshheading:9153219-Transcription, Genetic, pubmed-meshheading:9153219-Transcription Factor AP-1
pubmed:year
1997
pubmed:articleTitle
Lysophosphatidylcholine stimulates activator protein 1 and the c-Jun N-terminal kinase activity.
pubmed:affiliation
Division of Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.