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pubmed-article:9152225pubmed:abstractTextAge-related macular degeneration (AMD) is a genetically complex disorder. Tissue inhibitor of metalloproteinases-3 (TIMP3) on chromosome 22 has been identified as a gene that is mutated in Sosby's fundus dystrophy, an autosomal-dominant macular dystrophy that phenotypically resembles AMD. The purpose of this study was to determine whether TIMP3 is a major susceptibility gene for the AMD phenotype.lld:pubmed
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pubmed-article:9152225pubmed:articleTitleExclusion of TIMP3 as a candidate locus in age-related macular degeneration.lld:pubmed
pubmed-article:9152225pubmed:affiliationDepartment of Ophthalmology, Duke University Medical Center, Durham, North Carolina, USA.lld:pubmed
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