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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1997-7-18
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pubmed:abstractText |
Platelet factor 4 (PF-4) is a critical alpha chemokine in inflammation and injury responses, with multiple effects upon cellular activities. Discrete peptide sequences of the PF-4 molecule have been shown to retain biological activity. Our aim was to examine the influence of the PF-4 derived octapeptide (CT-112; TTSQVRPR) on type II collagen induced arthritis in mice, to determine if this peptide exhibited antiinflammatory properties.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CT 112,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen,
http://linkedlifedata.com/resource/pubmed/chemical/Concanavalin A,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogens,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet Factor 4,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrazolium Salts,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazolidinediones
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0315-162X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
890-8
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:9150077-Administration, Oral,
pubmed-meshheading:9150077-Amino Acid Sequence,
pubmed-meshheading:9150077-Animals,
pubmed-meshheading:9150077-Antibody Specificity,
pubmed-meshheading:9150077-Arthritis, Reactive,
pubmed-meshheading:9150077-Cell Division,
pubmed-meshheading:9150077-Cells, Cultured,
pubmed-meshheading:9150077-Collagen,
pubmed-meshheading:9150077-Concanavalin A,
pubmed-meshheading:9150077-Cytokines,
pubmed-meshheading:9150077-Disease Models, Animal,
pubmed-meshheading:9150077-Enzyme Inhibitors,
pubmed-meshheading:9150077-Lipopolysaccharides,
pubmed-meshheading:9150077-Mice,
pubmed-meshheading:9150077-Mice, Inbred DBA,
pubmed-meshheading:9150077-Mitogens,
pubmed-meshheading:9150077-Peptide Fragments,
pubmed-meshheading:9150077-Platelet Factor 4,
pubmed-meshheading:9150077-Spleen,
pubmed-meshheading:9150077-Tetrazolium Salts,
pubmed-meshheading:9150077-Thiazoles,
pubmed-meshheading:9150077-Thiazolidinediones
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pubmed:year |
1997
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pubmed:articleTitle |
A peptide sequence from platelet factor 4 (CT-112) is effective in the treatment of type II collagen induced arthritis in mice.
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pubmed:affiliation |
Division of Rheumatology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.
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pubmed:publicationType |
Journal Article
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