Linked Life Data

9149891

Source:http://linkedlifedata.com/resource/pubmed/id/9149891

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1997-8-7
pubmed:abstractText
Epidemiological studies suggest that bladder cancer may be caused by carcinogens in tobacco and certain occupational exposures. Molecular studies have shown that chromosome 9 alterations and TP53 mutations are the most frequent events in bladder cancer. To date, the relationships between epidemiological risk factors and genetic alterations have not been fully explored in bladder cancer. The purpose of this study was to explore the association between smoking and chromosome 9 aberrations in bladder cancer cases. Seventy-three patients with bladder cancer at Memorial Sloan-Kettering Cancer Center were evaluated for smoking history, occupational history, and chromosome 9 alterations. The epidemiological data were abstracted from medical charts. Patients' tumor tissues were analyzed using RFLP and microsatellite polymorphism assays for detection of chromosome 9 alterations. Elevated odds ratios (ORs) were found for chromosome 9 alterations in smokers compared to those in nonsmokers (OR = 4.2; 95% confidence interval, 1.02-17.0) after controlling for age, sex, race, occupational history, and stage of disease. The ORs were 3.6 for those smoking < or = 20 cigarettes per day and 5.8 for those smoking > 20 cigarettes per day. No association was found between occupational history and chromosome 9 alterations. This study supplies evidence suggestive of the link between smoking and chromosome 9 alterations in the etiology of bladder cancer and indicates that potential tumor suppressor genes on chromosome 9 may be involved in smoking-related bladder carcinogenesis.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1055-9965
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
321-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:9149891-Chromosome Aberrations, pubmed-meshheading:9149891-Chromosome Mapping, pubmed-meshheading:9149891-Chromosomes, Human, Pair 9, pubmed-meshheading:9149891-Cocarcinogenesis, pubmed-meshheading:9149891-Confidence Intervals, pubmed-meshheading:9149891-Gene Expression Regulation, Neoplastic, pubmed-meshheading:9149891-Genes, Tumor Suppressor, pubmed-meshheading:9149891-Humans, pubmed-meshheading:9149891-Occupational Exposure, pubmed-meshheading:9149891-Odds Ratio, pubmed-meshheading:9149891-Polymerase Chain Reaction, pubmed-meshheading:9149891-Polymorphism, Restriction Fragment Length, pubmed-meshheading:9149891-Smoking, pubmed-meshheading:9149891-Tumor Suppressor Protein p53, pubmed-meshheading:9149891-Urinary Bladder, pubmed-meshheading:9149891-Urinary Bladder Neoplasms
pubmed:year
1997
pubmed:articleTitle
Cigarette smoking and chromosome 9 alterations in bladder cancer.
pubmed:affiliation
Department of Epidemiology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. zhang@biosta.mskcc.org
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.