Linked Life Data

9147928

Source:http://linkedlifedata.com/resource/pubmed/id/9147928

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1997-5-12
pubmed:abstractText
The effect of intra-arterial versus intravenous infusion of cisplatinum on the histological response of osteosarcoma of the limbs was evaluated based on the results of three studies in which CDP was preoperatively associated with MTX and ADM (1st study), and with MTX, ADM, and IFO (2nd and 3rd studies). In the chemotherapeutic protocol that involved 3 drugs the percentage of "good histological responses to chemotherapy" (defined as tumor necrosis > 90%) was significantly higher in the 40 patients who were administered CDP by intra-arterial infusion as compared to that observed in the 39 patients treated with CDP by intravenous route (78% versus 46%: P .004). In the two sequential studies where 4 drugs were used, the percentage of good histological responses was essentially the same for patients treated with CDP administered intravenously, and for those treated with CDP administered intra-arterially (78% versus 84%). Regardless of the route of infusion used to administer cisplatinum the percentage of "good" histological responses was significantly higher in the 109 patients treated with the 4-drug protocol as compared to the 79 patients treated with the 3-drug protocol (82% vs 62%; P .04). This difference may essentially be attributed to the higher percentage of good responses observed in the 4-drug protocol in patients treated with CDP administered intravenously (78% vs 46% for patients treated i.v. with the 3-drug protocol; P .006). For the patients instead treated with CDP administered intra-arterially the percentage of good responses was essentially the same with the 4-drug protocol and with the 3-drug protocol (84% vs 78%; P ns). These data lead us to conclude that in the neoadjuvant treatment of osteosarcoma of the limbs a preoperative 4-drug protocol (MTX, CDP, ADM, IFO) is more effective than a 3-drug protocol (MTX, CDP, ADM), and that in a 4-drug preoperative chemotherapy protocol intra-arterial infusion of CDP does not offer particular advantages as compared to intravenous infusion.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0009-4749
pubmed:author
pubmed:issnType
Print
pubmed:volume
81
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
369-82
pubmed:dateRevised
2010-6-18
pubmed:meshHeading
pubmed-meshheading:9147928-Adolescent, pubmed-meshheading:9147928-Adult, pubmed-meshheading:9147928-Antibiotics, Antineoplastic, pubmed-meshheading:9147928-Antimetabolites, Antineoplastic, pubmed-meshheading:9147928-Antineoplastic Agents, Alkylating, pubmed-meshheading:9147928-Antineoplastic Combined Chemotherapy Protocols, pubmed-meshheading:9147928-Bone Neoplasms, pubmed-meshheading:9147928-Chemotherapy, Adjuvant, pubmed-meshheading:9147928-Cisplatin, pubmed-meshheading:9147928-Combined Modality Therapy, pubmed-meshheading:9147928-Doxorubicin, pubmed-meshheading:9147928-Extremities, pubmed-meshheading:9147928-Female, pubmed-meshheading:9147928-Humans, pubmed-meshheading:9147928-Ifosfamide, pubmed-meshheading:9147928-Infusions, Intra-Arterial, pubmed-meshheading:9147928-Infusions, Intravenous, pubmed-meshheading:9147928-Male, pubmed-meshheading:9147928-Methotrexate, pubmed-meshheading:9147928-Neoplasm Metastasis, pubmed-meshheading:9147928-Osteosarcoma, pubmed-meshheading:9147928-Preoperative Care
pubmed:articleTitle
The effect of intra-arterial versus intravenous cisplatinum in the neoadjuvant treatment of osteosarcoma of the limbs: the experience at the Rizzoli Institute.
pubmed:affiliation
Sezione di Chemioterapia, Istituti Ortopedici Rizzoli, Bologna.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Multicenter Study