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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
20
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pubmed:dateCreated |
1997-5-15
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pubmed:abstractText |
Germ-line mutations in the BRCA1 and BRCA2 genes predispose women to breast cancer. BRCA1 mutations are found in approximately 12 percent of women with breast cancer of early onset, and the specific mutation causing a deletion of adenine and guanine (185delAG), which is present in 1 percent of the Ashkenazi Jewish population, contributes to 21 percent of breast cancers among young Jewish women. The contribution of BRCA2 mutations to breast cancer of early onset is unknown.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0028-4793
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pubmed:author |
pubmed-author:BowcockAA,
pubmed-author:FinkelsteinD MDM,
pubmed-author:FitzGeraldM GMG,
pubmed-author:HaberD ADA,
pubmed-author:IshiokaCC,
pubmed-author:IsselbacherK JKJ,
pubmed-author:KanamaruRR,
pubmed-author:KrainerMM,
pubmed-author:MacDonaldD JDJ,
pubmed-author:ShimadaAA,
pubmed-author:Silva-ArrietaSS,
pubmed-author:UnsalHH
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
336
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1416-21
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9145678-Adult,
pubmed-meshheading:9145678-Age of Onset,
pubmed-meshheading:9145678-BRCA2 Protein,
pubmed-meshheading:9145678-Breast Neoplasms,
pubmed-meshheading:9145678-DNA Mutational Analysis,
pubmed-meshheading:9145678-Female,
pubmed-meshheading:9145678-Frameshift Mutation,
pubmed-meshheading:9145678-Genes, BRCA1,
pubmed-meshheading:9145678-Germ-Line Mutation,
pubmed-meshheading:9145678-Heterozygote,
pubmed-meshheading:9145678-Humans,
pubmed-meshheading:9145678-Neoplasm Proteins,
pubmed-meshheading:9145678-Prevalence,
pubmed-meshheading:9145678-Risk,
pubmed-meshheading:9145678-Transcription Factors
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pubmed:year |
1997
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pubmed:articleTitle |
Differential contributions of BRCA1 and BRCA2 to early-onset breast cancer.
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pubmed:affiliation |
Center for Cancer Risk Analysis and the Massachusetts General Hospital Cancer Center, Charlestown 02129, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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