Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1997-7-18
pubmed:abstractText
Nonsteroidal antiandrogen casodex and steroidal antiandrogen epitestosterone were administered to intact male mice, and their effect on femoral bones and circulating calcium, phosphate, testosterone, and LH were compared with controls and castrated animals. Pure antiandrogen casodex in a dose used in humans for treatment of prostate cancer decreased the weight of seminal vesicles, organ which is highly sensitive to the androgenic effect, increased insignificantly the concentration of LH and of testosterone, but did not have any effect on bone density or mineral content of bone. Epitestosterone, which not only inhibits the binding of androgens to their receptors but also inhibits the formation of dihydrotestosterone from testosterone, and is reported to interfere with aromatization of testosterone to estrogens, decreased the bone density, ash weight, and calcium and phosphate content of femoral bone tissue significantly, although not to values as low as those seen in castrated animals.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
8756-3282
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
473-5
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:9145245-Androgen Antagonists, pubmed-meshheading:9145245-Anilides, pubmed-meshheading:9145245-Animals, pubmed-meshheading:9145245-Bone Density, pubmed-meshheading:9145245-Bone Diseases, Metabolic, pubmed-meshheading:9145245-Bone and Bones, pubmed-meshheading:9145245-Calcium, pubmed-meshheading:9145245-Epitestosterone, pubmed-meshheading:9145245-Humans, pubmed-meshheading:9145245-Luteinizing Hormone, pubmed-meshheading:9145245-Male, pubmed-meshheading:9145245-Mice, pubmed-meshheading:9145245-Nitriles, pubmed-meshheading:9145245-Orchiectomy, pubmed-meshheading:9145245-Organ Size, pubmed-meshheading:9145245-Phosphates, pubmed-meshheading:9145245-Risk Factors, pubmed-meshheading:9145245-Seminal Vesicles, pubmed-meshheading:9145245-Testis, pubmed-meshheading:9145245-Testosterone, pubmed-meshheading:9145245-Tosyl Compounds
pubmed:year
1997
pubmed:articleTitle
Effect of antiandrogens casodex and epitestosterone on bone composition in mice.
pubmed:affiliation
Third Medical Clinic, First Medical Faculty, Charles University, Prague, Czech Republic.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't