Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
1997-6-2
|
| pubmed:abstractText |
Two siblings with a peptide TAP deficiency were recently described. Despite poor cell surface expression of HLA class I molecules, these patients were not unusually susceptible to viral infections. The majority of the cell surface-expressed class I molecules were HLA-B products as assessed by cytofluorometry and biochemical analysis. Analysis of two peptides eluted from the class I molecules expressed by TAP-deficient EBV B lymphoblastoid cell lines indicated that both were derived from cytosolic proteins and presented by HLA-B molecules. Peripheral alphabeta CD8+ T cells were present and their TCR repertoire was polyclonal. Most of the alphabeta CD8+ T cell clones studied (21 of 22) were nonreactive against cells expressing normal levels of the same HLA alleles as those of the TAP-deficient patients. However, it was possible to isolate one cytotoxic CD8+ alphabeta T cell clone recognizing the EBV protein LMP2 presented by HLA-B molecules on TAP-deficient cells. These observations suggest that in the TAP-deficient patients, CD8+ alphabeta T cells could mature and be recruited in immune responses to mediate HLA class I-restricted cytotoxic defense against viral infections. They also strengthen the physiologic importance of a TAP-independent processing pathway of the LMP2 protein, which was previously shown to contain several other TAP-independent epitopes.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ATP-Binding Cassette Transporters,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-B Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...,
http://linkedlifedata.com/resource/pubmed/chemical/TAP2 protein, human
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0022-1767
|
| pubmed:author |
pubmed-author:ArnoldDD,
pubmed-author:BausingerHH,
pubmed-author:BiddisonWW,
pubmed-author:BonnevilleMM,
pubmed-author:CazenaveJ PJP,
pubmed-author:DonatoLL,
pubmed-author:FrickerDD,
pubmed-author:GomardEE,
pubmed-author:HanasJJ,
pubmed-author:HoussaintEE,
pubmed-author:KERNAHAND ADA,
pubmed-author:LehnerPP,
pubmed-author:PeyratM AMA,
pubmed-author:RammenseeH GHG,
pubmed-author:SalameroJJ,
pubmed-author:SasportesMM,
pubmed-author:StevanovicSS,
pubmed-author:TongioM MMM,
pubmed-author:UytdeHaagFF,
pubmed-author:de la SalleHH
|
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
158
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
4555-63
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9144467-ATP-Binding Cassette Transporters,
pubmed-meshheading:9144467-Antigen-Presenting Cells,
pubmed-meshheading:9144467-Antigens, Viral,
pubmed-meshheading:9144467-CD8-Positive T-Lymphocytes,
pubmed-meshheading:9144467-Cytotoxicity, Immunologic,
pubmed-meshheading:9144467-HLA-B Antigens,
pubmed-meshheading:9144467-Herpesvirus 4, Human,
pubmed-meshheading:9144467-Humans,
pubmed-meshheading:9144467-Immunologic Deficiency Syndromes,
pubmed-meshheading:9144467-Lymphocyte Activation,
pubmed-meshheading:9144467-Peptides,
pubmed-meshheading:9144467-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:9144467-T-Lymphocyte Subsets
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Human peptide transporter deficiency: importance of HLA-B in the presentation of TAP-independent EBV antigens.
|
| pubmed:affiliation |
Histocompatibility Laboratory, Contract for Young Research Unit INSERM 94-03 and INSERM Unit 311, Blood Transfusion Establishment, Strasbourg, France.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|