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9143866
Source:
http://linkedlifedata.com/resource/pubmed/id/9143866
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Statements in which the resource exists as a subject.
Predicate
Object
rdf:type
pubmed:Citation
lifeskim:mentions
umls-concept:C0009214
,
umls-concept:C0026030
,
umls-concept:C0086418
,
umls-concept:C0243077
,
umls-concept:C1280500
pubmed:issue
1
pubmed:dateCreated
1997-8-21
pubmed:abstractText
The O- and N-demethylation of codeine is catalysed by CYP2D6 and CYP3A4 respectively. The formation rates of morphine by O-demethylation and norcodeine by N-demethylation were studied in two sets of human liver microsomes.
pubmed:language
eng
pubmed:journal
http://linkedlifedata.com/resource/pubmed/journal/1256165
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/CYP3A protein, human
,
http://linkedlifedata.com/resource/pubmed/chemical/CYP3A4 protein, human
,
http://linkedlifedata.com/resource/pubmed/chemical/Codeine
,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP2D6
,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP3A
,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 Enzyme System
,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors
,
http://linkedlifedata.com/resource/pubmed/chemical/Mixed Function Oxygenases
pubmed:status
MEDLINE
pubmed:issn
0031-6970
pubmed:author
pubmed-author:SäweJJ
,
pubmed-author:YueQ YQY
pubmed:issnType
Print
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
41-7
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:9143866-Codeine
,
pubmed-meshheading:9143866-Cytochrome P-450 CYP2D6
,
pubmed-meshheading:9143866-Cytochrome P-450 CYP3A
,
pubmed-meshheading:9143866-Cytochrome P-450 Enzyme System
,
pubmed-meshheading:9143866-Drug Evaluation, Preclinical
,
pubmed-meshheading:9143866-Enzyme Inhibitors
,
pubmed-meshheading:9143866-Humans
,
pubmed-meshheading:9143866-Microsomes, Liver
,
pubmed-meshheading:9143866-Mixed Function Oxygenases
pubmed:year
1997
pubmed:articleTitle
Different effects of inhibitors on the O- and N-demethylation of codeine in human liver microsomes.
pubmed:affiliation
Department of Clinical Pharmacology, Huddinge University Hospital, Sweden.
pubmed:publicationType
Journal Article
,
Comparative Study
,
In Vitro
,
Research Support, Non-U.S. Gov't