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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1997-6-4
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pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U59132,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U59133,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U59134,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U59135,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U59136,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U59137,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U59138,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U59139,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U59140,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U59141,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U59142,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U59143,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U59144
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pubmed:abstractText |
Evolutionary associations of human and simian T-cell leukemia/lymphotropic viruses I and II (HTLV-I/II and STLV-I/II) are inferred from phylogenetic analysis of tax gene sequences. Samples studied consisted of a geographically diverse assemblage of viral strains obtained from 10 human subjects and 20 individuals representing 12 species of nonhuman primates. Sequence analyses identified distinct substitutions, which distinguished between viral types I and II, irrespective of host species. Phylogenetic reconstruction of nucleotide sequences strongly supported two major evolutionary groups corresponding to viral types I and II. With the type I lineage, clusters were composed of strains from multiple host species. A genetically diverse, monophyletic lineage consisting of eight new viral strains from several species of Asian macaques was identified. The second lineage consisted of a monophyletic assemblage of HTLV-II/STLV-II strains from Africa and the New World, including an isolate from a pygmy chimp (Pan paniscus) as an early divergence within the lineage. High levels of genetic variation among strains from Asian STLV-I macaque suggest the virus arose in Asia. Evidence of the origin of the type II virus is less clear, but diversity among HTLV-II variants from a single isolated population of Mbati villagers is suggestive but not proof of an African origin.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0042-6822
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pubmed:author |
pubmed-author:AnthonyRR,
pubmed-author:DesrosiersR CRC,
pubmed-author:FranchiniGG,
pubmed-author:GessainAA,
pubmed-author:GireMM,
pubmed-author:HeneineWW,
pubmed-author:HervaRR,
pubmed-author:IskandriatiDD,
pubmed-author:McClurgJJ,
pubmed-author:O'BrienS JSJ,
pubmed-author:PamungkasJJ,
pubmed-author:RichardsA LAL,
pubmed-author:RivadeneiraEE,
pubmed-author:RosenLL,
pubmed-author:SlatteryJ PJP
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pubmed:issnType |
Print
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pubmed:day |
28
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pubmed:volume |
231
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
96-104
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:9143307-Amino Acid Sequence,
pubmed-meshheading:9143307-Animals,
pubmed-meshheading:9143307-Base Sequence,
pubmed-meshheading:9143307-DNA, Viral,
pubmed-meshheading:9143307-Gene Products, tax,
pubmed-meshheading:9143307-Genes, Viral,
pubmed-meshheading:9143307-Human T-lymphotropic virus 1,
pubmed-meshheading:9143307-Human T-lymphotropic virus 2,
pubmed-meshheading:9143307-Humans,
pubmed-meshheading:9143307-Molecular Sequence Data,
pubmed-meshheading:9143307-Phylogeny,
pubmed-meshheading:9143307-Primates,
pubmed-meshheading:9143307-Sequence Analysis, DNA,
pubmed-meshheading:9143307-Sequence Homology, Amino Acid,
pubmed-meshheading:9143307-Sequence Homology, Nucleic Acid,
pubmed-meshheading:9143307-Simian T-lymphotropic virus 1
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pubmed:year |
1997
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pubmed:articleTitle |
The tax gene sequences form two divergent monophyletic lineages corresponding to types I and II of simian and human T-cell leukemia/lymphotropic viruses.
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pubmed:affiliation |
Basic Research Laboratory, National Cancer Institute, Bethesda, Maryland 20892, USA.
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pubmed:publicationType |
Journal Article
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