Linked Life Data

9142997

Source:http://linkedlifedata.com/resource/pubmed/id/9142997

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1997-7-18
pubmed:abstractText
Neuropeptide Y increases feeding and decreases measures of brown adipose tissue thermogenesis. In lactating rats, increased feeding, increased hypothalamic neuropeptide Y neuroactivity and decreased thermogenesis occur. Naltrexone is an opioid receptor antagonist which decreases neuropeptide Y-induced feeding and reverse neuropeptide Y-induced decreases in brown adipose tissue thermogenesis. We hypothesized that opioid receptors are involved in neuropeptide Y neuroactivity during lactation. To see if naltrexone would alter feeding neuropeptide Y gene expression in the arcuate nucleus, neuropeptide Y levels in the paraventricular nucleus, and uncoupling protein gene expression in brown adipose tissue of lactating rats, osmotic minipumps pre-filled with either 0.9% saline or naltrexone (70 micrograms/h) were implanted subcutaneously in 47 female Sprague-Dawley rats weighing 309 +/- 5 g. Half these rats were studied on days 10-16 of lactation, and the other half were studied 7 days after lactation. After 48 h, neuropeptide Y mRNA levels and uncoupling protein mRNA levels were determined using specific cDNA probes. Neuropeptide Y peptide levels in the paraventricular nucleus were measured by radioimmunoassay. Naltrexone decreased food intake by 26% in the postlactating rats, but had no effect on feeding in the lactating animals. Lactation resulted in significantly increased arcuate neuropeptide Y mRNA, decreased neuropeptide Y levels in the paraventricular nucleus and decreased brown adipose tissue uncoupling protein mRNA levels. Naltrexone did not influence any of these parameters. Thus, the alterations in neuropeptide Y neuroactivity and brown fat thermogenesis which occur in lactation is not altered by generalized opioid receptor blockade.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0028-3835
pubmed:author
pubmed:issnType
Print
pubmed:volume
65
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
259-64
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Effect of naltrexone on feeding, neuropeptide Y and uncoupling protein gene expression during lactation.
pubmed:affiliation
Department of Food Science and Nutrition, University of Minnesota, Saint Paul, Minneapolis, Minn., USA. kotzx004@maroon.te.umn.edu
pubmed:publicationType
Journal Article