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pubmed-article:9142008pubmed:abstractTextIntermittent claudication due to peripheral arterial occlusive disease (PAOD) is a common cause of pain and disability in the middle-aged. Clinical trials of the potent vasodilator prostaglandin E1 have been disappointing. This is the first report of a controlled clinical trial of AS-0:3, a novel prodrug of prostaglandin E1 incorporated into lipid microspheres that has been developed to improve delivery of the active compound to blood vessel walls.lld:pubmed
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pubmed-article:9142008pubmed:pagination2298-302lld:pubmed
pubmed-article:9142008pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:9142008pubmed:articleTitleRandomized, double-blind, placebo-controlled study evaluating the efficacy and safety of AS-013, a prostaglandin E1 prodrug, in patients with intermittent claudication.lld:pubmed
pubmed-article:9142008pubmed:affiliationNinewells Hospital and Medical School, Dundee, UK.lld:pubmed
pubmed-article:9142008pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9142008pubmed:publicationTypeClinical Triallld:pubmed
pubmed-article:9142008pubmed:publicationTypeRandomized Controlled Triallld:pubmed
pubmed-article:9142008pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
pubmed-article:9142008pubmed:publicationTypeMulticenter Studylld:pubmed