| pubmed-article:9141429 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9141429 | lifeskim:mentions | umls-concept:C0023911 | lld:lifeskim |
| pubmed-article:9141429 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:9141429 | lifeskim:mentions | umls-concept:C0752312 | lld:lifeskim |
| pubmed-article:9141429 | lifeskim:mentions | umls-concept:C0035124 | lld:lifeskim |
| pubmed-article:9141429 | lifeskim:mentions | umls-concept:C1515877 | lld:lifeskim |
| pubmed-article:9141429 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:9141429 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:9141429 | pubmed:dateCreated | 1997-5-28 | lld:pubmed |
| pubmed-article:9141429 | pubmed:abstractText | The injury resulting from cold ischemia and warm reperfusion during liver transplantation is a major clinical problem that limits graft success. Kupffer cell activation plays a pivotal role in reperfusion injury, and Kupffer cell products, including free radicals and tumor necrosis factor alpha (TNF-alpha), are implicated as damaging agents. However, the second messengers and signaling pathways that are activated by the stress of hepatic ischemia/reperfusion remain unknown. The purpose of this study is to assess the activation of the three known vertebrate mitogen activated protein kinase (MAPKs) and the activating protein 1 (AP-1) transcription factor in response to ischemia and reperfusion in the transplanted rat liver. There was a potent, sustained induction of c-jun N-terminal kinase (JNK), but not of the related MAPKs extracellular signal-regulated kinases (ERK) or p38, upon reperfusion after transplantation. TNF-alpha messenger RNA (mRNA) levels and transcription factors AP-1 and nuclear factor-kappaB (NF-kappaB) were induced in the liver after 60 minutes of reperfusion. Finally, there was an elevation of ceramide, but not diacylglycerol or sphingosine, in the transplanted liver. Ceramide is a second messenger generated by TNF-alpha treatment and is an activator of JNK. Because JNK activation preceded the elevations in ceramide and TNF-alpha mRNA, these results suggest that increased hepatic TNF-alpha and ceramide may perpetuate JNK induction, but that they are not the initiating signals of JNK activation during reperfusion injury in the transplanted liver. | lld:pubmed |
| pubmed-article:9141429 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9141429 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9141429 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9141429 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9141429 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9141429 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9141429 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9141429 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9141429 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9141429 | pubmed:month | May | lld:pubmed |
| pubmed-article:9141429 | pubmed:issn | 0270-9139 | lld:pubmed |
| pubmed-article:9141429 | pubmed:author | pubmed-author:ThurmanR GRG | lld:pubmed |
| pubmed-article:9141429 | pubmed:author | pubmed-author:JenkinsGG | lld:pubmed |
| pubmed-article:9141429 | pubmed:author | pubmed-author:BrennerD ADA | lld:pubmed |
| pubmed-article:9141429 | pubmed:author | pubmed-author:GalPP | lld:pubmed |
| pubmed-article:9141429 | pubmed:author | pubmed-author:LemastersJ... | lld:pubmed |
| pubmed-article:9141429 | pubmed:author | pubmed-author:QianTT | lld:pubmed |
| pubmed-article:9141429 | pubmed:author | pubmed-author:JayadevSS | lld:pubmed |
| pubmed-article:9141429 | pubmed:author | pubmed-author:HannunYY | lld:pubmed |
| pubmed-article:9141429 | pubmed:author | pubmed-author:StachlewitzR... | lld:pubmed |
| pubmed-article:9141429 | pubmed:author | pubmed-author:BradhamC ACA | lld:pubmed |
| pubmed-article:9141429 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9141429 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:9141429 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9141429 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9141429 | pubmed:pagination | 1128-35 | lld:pubmed |
| pubmed-article:9141429 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:9141429 | pubmed:meshHeading | pubmed-meshheading:9141429-... | lld:pubmed |
| pubmed-article:9141429 | pubmed:meshHeading | pubmed-meshheading:9141429-... | lld:pubmed |
| pubmed-article:9141429 | pubmed:meshHeading | pubmed-meshheading:9141429-... | lld:pubmed |
| pubmed-article:9141429 | pubmed:meshHeading | pubmed-meshheading:9141429-... | lld:pubmed |
| pubmed-article:9141429 | pubmed:meshHeading | pubmed-meshheading:9141429-... | lld:pubmed |
| pubmed-article:9141429 | pubmed:meshHeading | pubmed-meshheading:9141429-... | lld:pubmed |
| pubmed-article:9141429 | pubmed:meshHeading | pubmed-meshheading:9141429-... | lld:pubmed |
| pubmed-article:9141429 | pubmed:meshHeading | pubmed-meshheading:9141429-... | lld:pubmed |
| pubmed-article:9141429 | pubmed:meshHeading | pubmed-meshheading:9141429-... | lld:pubmed |
| pubmed-article:9141429 | pubmed:meshHeading | pubmed-meshheading:9141429-... | lld:pubmed |
| pubmed-article:9141429 | pubmed:meshHeading | pubmed-meshheading:9141429-... | lld:pubmed |
| pubmed-article:9141429 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9141429 | pubmed:articleTitle | Reperfusion after liver transplantation in rats differentially activates the mitogen-activated protein kinases. | lld:pubmed |
| pubmed-article:9141429 | pubmed:affiliation | Department of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, 27599, USA. | lld:pubmed |
| pubmed-article:9141429 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9141429 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9141429 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9141429 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9141429 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9141429 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9141429 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9141429 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9141429 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9141429 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9141429 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9141429 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9141429 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9141429 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9141429 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9141429 | lld:pubmed |
