Linked Life Data

9141089

Source:http://linkedlifedata.com/resource/pubmed/id/9141089

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1997-7-14
pubmed:abstractText
There is increasing evidence that carbon monoxide (CO), like nitric oxide (NO), may be a neuronal messenger molecule. This study investigated the expression of heme oxygenase-2 (HO-2), the enzyme responsible for the synthesis of CO, by intracardiac neurones. Many, if not all newborn guinea-pig intracardiac neurones in culture were HO-2-immunoreactive. Furthermore, double labelling showed that a relatively small subpopulation of these neurones also expressed NO synthase/nicotinamide dinucleotide phosphate (NADPH)-diaphorase (NOS/NADPH-d) activity. These findings suggest that intracardiac neurones can synthesize CO and that CO may be fundamental to their function. Comparison of the proportions of intracardiac neurones that contain HO-2 with those that express NOS/NADPH-d activity also indicates that CO may be more important than NO in the intrinsic neuronal control of the heart.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:day
3
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1043-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Heme oxygenase-2 and nitric oxide synthase in guinea-pig intracardiac neurones.
pubmed:affiliation
Department of Anatomy and Developmental Biology, University College London, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't