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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4 Pt 2
|
| pubmed:dateCreated |
1997-5-28
|
| pubmed:abstractText |
The effects of administering 8-hydroxy-2-(di-n-propylamine) tetralin [8-OH-DPAT, a serotonin 1A (5-HT1A) receptor agonist] into the rostral ventrolateral medulla (RVLM) on cardiovascular responses during tibial nerve stimulation-evoked muscle contraction were investigated using anesthetized rats. Stimulation of the tibial nerve (3 times motor threshold, 0.1 ms, 40 Hz) for 30 s increased mean arterial pressure (MAP), heart rate (HR), and muscle tension by 25 +/- 3 mmHg, 24 +/- 4 beats/min, and 299 +/- 35 g, respectively. Bilateral microdialysis of 8-OH-DPAT (10 mM) for 30 min attenuated the stimulation-evoked increases in MAP (8 +/- 2 mmHg) and HR (11 +/- 5 beats/min), without a change in muscle tension (292 +/- 30 g). However, administration of 1 mM 8-OH-DPAT had no effect on the cardiovascular responses. Thirty minutes of microdialysis of 8-OH-DPAT (10 mM) into the caudal ventrolateral medulla produced no effect on cardiovascular responses during muscle contraction. Prior administration of 10 mM 1-[2-methoxyphenyl]-4-[4-(2-phthalimido)-butyl]piperazine (NAN-190), a 5-HT1A receptor antagonist, for 30 min into the RVLM blocked the attenuating effects of subsequent microdialysis of 8-OH-DPAT (10 mM). Results suggest that activation of 5-HT1A receptors within the RVLM inhibit cardiovascular responses elicited during static muscle contraction.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/8-Hydroxy-2-(di-n-propylamino)tetral...,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Neuromuscular Depolarizing Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin, 5-HT1,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Receptor Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Tubocurarine
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0002-9513
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
272
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
R1020-7
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:9139996-8-Hydroxy-2-(di-n-propylamino)tetralin,
pubmed-meshheading:9139996-Animals,
pubmed-meshheading:9139996-Blood Pressure,
pubmed-meshheading:9139996-Glutamic Acid,
pubmed-meshheading:9139996-Heart Rate,
pubmed-meshheading:9139996-Male,
pubmed-meshheading:9139996-Medulla Oblongata,
pubmed-meshheading:9139996-Microdialysis,
pubmed-meshheading:9139996-Muscle, Skeletal,
pubmed-meshheading:9139996-Muscle Contraction,
pubmed-meshheading:9139996-Neuromuscular Depolarizing Agents,
pubmed-meshheading:9139996-Rats,
pubmed-meshheading:9139996-Rats, Sprague-Dawley,
pubmed-meshheading:9139996-Receptors, Serotonin,
pubmed-meshheading:9139996-Receptors, Serotonin, 5-HT1,
pubmed-meshheading:9139996-Serotonin Receptor Agonists,
pubmed-meshheading:9139996-Tibial Nerve,
pubmed-meshheading:9139996-Tubocurarine
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Central 5-HT1A modulation of cardiovascular responses to tibial nerve stimulation-evoked muscle contraction.
|
| pubmed:affiliation |
Department of Pharmacology, University of New England College of Osteopathic Medicine, Biddeford, Maine 04005, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|