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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4 Pt 2
|
| pubmed:dateCreated |
1997-5-28
|
| pubmed:abstractText |
The purpose of the present study was to determine 1) whether different organs undergo similar increase in vascular resistance in Dahl-Iwai salt-sensitive (S) rats, and 2) the effects of chronic oral L-arginine supplementation on the regional hemodynamics in S rats. Male 6-wk-old S rats and salt-resistant (R) rats were maintained on an 8% NaCl chow for 4 wk. One group (S or R rats) was maintained on tap water and the other group (S/Arg or R/Arg rats) received tap water containing L-arginine at a concentration of 1.5%. Organ blood flow and cardiac output were measured with microspheres in the conscious condition. Mean blood pressure in S, S/Arg, R, and R/Arg rats was 159 +/- 5, 138 +/- 3, 111 +/- 4, and 112 +/- 4 mmHg, respectively. Urinary excretion of protein and albumin in S/Arg rats was significantly suppressed compared with S rats. Concerning regional hemodynamics, the flow rate of the kidney was lower in S rats than in R rats, but there were no differences between S and R rats in the flow rates of the brain, heart, lung, liver, spleen, intestine, skeletal muscle, and skin. Thus the renal blood flow was solely reduced in S rats on a high-salt diet. The flow rate of the kidney in S/Arg rats was maintained at a higher level compared with that of S rats. L-Arginine treatment tended to produce a recovery in the urinary excretion of guanosine 3',5'-cyclic monophosphate in S rats, but had no effect in R rats. Thus the supplementation of L-arginine prevented the increase in blood pressure in S rats on a high-salt diet and normalized the abnormality of renal hemodynamics accompanying salt-induced hypertension.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0002-9513
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
272
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
R1013-9
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9139995-Animals,
pubmed-meshheading:9139995-Arginine,
pubmed-meshheading:9139995-Blood Pressure,
pubmed-meshheading:9139995-Brain,
pubmed-meshheading:9139995-Cardiac Output,
pubmed-meshheading:9139995-Coronary Circulation,
pubmed-meshheading:9139995-Food, Fortified,
pubmed-meshheading:9139995-Heart Rate,
pubmed-meshheading:9139995-Hemodynamics,
pubmed-meshheading:9139995-Intestine, Small,
pubmed-meshheading:9139995-Kidney,
pubmed-meshheading:9139995-Liver,
pubmed-meshheading:9139995-Male,
pubmed-meshheading:9139995-Organ Specificity,
pubmed-meshheading:9139995-Rats,
pubmed-meshheading:9139995-Rats, Inbred Strains,
pubmed-meshheading:9139995-Regional Blood Flow,
pubmed-meshheading:9139995-Sodium, Dietary,
pubmed-meshheading:9139995-Species Specificity,
pubmed-meshheading:9139995-Testis,
pubmed-meshheading:9139995-Vascular Resistance
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Regional blood flow in Dahl-Iwai salt-sensitive rats and the effects of dietary L-arginine supplementation.
|
| pubmed:affiliation |
Department of Pharmacology, Kagawa Medical School, Japan.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|