pubmed-article:9139826 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:9139826 | lifeskim:mentions | umls-concept:C0680022 | lld:lifeskim |
pubmed-article:9139826 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
pubmed-article:9139826 | lifeskim:mentions | umls-concept:C0242692 | lld:lifeskim |
pubmed-article:9139826 | lifeskim:mentions | umls-concept:C0040690 | lld:lifeskim |
pubmed-article:9139826 | lifeskim:mentions | umls-concept:C0240417 | lld:lifeskim |
pubmed-article:9139826 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
pubmed-article:9139826 | lifeskim:mentions | umls-concept:C1883220 | lld:lifeskim |
pubmed-article:9139826 | pubmed:issue | 6628 | lld:pubmed |
pubmed-article:9139826 | pubmed:dateCreated | 1997-5-21 | lld:pubmed |
pubmed-article:9139826 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9139826 | pubmed:abstractText | The transforming growth factor-beta (TGF-beta) superfamily encompasses a large group of growth and differentiation factors playing important roles in regulating embryonic development and in maintaining tissue homeostasis in adult animals. Using degenerate polymerase chain reaction, we have identified a new murine TGF-beta family member, growth/differentiation factor-8 (GDF-8), which is expressed specifically in developing and adult skeletal muscle. During early stages of embryogenesis, GDF-8 expression is restricted to the myotome compartment of developing somites. At later stages and in adult animals, GDF-8 is expressed in many different muscles throughout the body. To determine the biological function of GDF-8, we disrupted the GDF-8 gene by gene targeting in mice. GDF-8 null animals are significantly larger than wild-type animals and show a large and widespread increase in skeletal muscle mass. Individual muscles of mutant animals weigh 2-3 times more than those of wild-type animals, and the increase in mass appears to result from a combination of muscle cell hyperplasia and hypertrophy. These results suggest that GDF-8 functions specifically as a negative regulator of skeletal muscle growth. | lld:pubmed |
pubmed-article:9139826 | pubmed:language | eng | lld:pubmed |
pubmed-article:9139826 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9139826 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:9139826 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9139826 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9139826 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:9139826 | pubmed:month | May | lld:pubmed |
pubmed-article:9139826 | pubmed:issn | 0028-0836 | lld:pubmed |
pubmed-article:9139826 | pubmed:author | pubmed-author:LeeS JSJ | lld:pubmed |
pubmed-article:9139826 | pubmed:author | pubmed-author:LawlerA MAM | lld:pubmed |
pubmed-article:9139826 | pubmed:author | pubmed-author:McPherronA... | lld:pubmed |
pubmed-article:9139826 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:9139826 | pubmed:day | 1 | lld:pubmed |
pubmed-article:9139826 | pubmed:volume | 387 | lld:pubmed |
pubmed-article:9139826 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:9139826 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:9139826 | pubmed:pagination | 83-90 | lld:pubmed |
pubmed-article:9139826 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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pubmed-article:9139826 | pubmed:year | 1997 | lld:pubmed |
pubmed-article:9139826 | pubmed:articleTitle | Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. | lld:pubmed |
pubmed-article:9139826 | pubmed:affiliation | Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. | lld:pubmed |
pubmed-article:9139826 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:9139826 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
pubmed-article:9139826 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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