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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1997-5-5
|
| pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/D90600,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/D90601,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U36380,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U44402,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U45966
|
| pubmed:abstractText |
Infection with putative non-A to E hepatitis virus, designated GB virus C (GBV-C), was surveyed in 286 patients with chronic liver disease in Japan. RNA of GBV-C was detected, by reverse-transcription polymerase chain reaction with nested primers from the 5'-noncoding region, in 19 patients (6.6%) at a frequency higher (P < 0.001) than in three of 275 (1.1%) normal controls. It was detected in three of 83 (4%) patients with hepatitis B virus infection, 15 of 188 (8%) patients with hepatitis C virus infection, and one of 12 (8%) patients without evidence of ongoing infection with hepatitis B or C virus. GBV-C RNA was detected in nine of 186 (5%) patients with chronic hepatitis aged 51.2 +/- 13.3 years, six of 64 (9%) with liver cirrhosis aged 62.9 +/- 11.4 years, and four of 36 (11%) with hepatocellular carcinoma aged 62.0 +/- 11.1 years. Nucleotide sequences of 100 base pairs in the helicase region of GBV-C isolates from the 19 patients varied up to 21%, while sequences of 33 deduced amino acids were conserved and differed only by up to 6%. These results indicate that infection with GBV-C in patients with non-B, non-C chronic liver disease would not be frequent, although the sensitivity of the detection method could be improved. Coinfection of GBV-C with hepatitis B or C virus, as well as the duration of infection, might accelerate the progression of chronic liver disease.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0146-6615
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
51
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
175-81
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9139080-Amino Acid Sequence,
pubmed-meshheading:9139080-Base Sequence,
pubmed-meshheading:9139080-Blood Transfusion,
pubmed-meshheading:9139080-Conserved Sequence,
pubmed-meshheading:9139080-DNA Helicases,
pubmed-meshheading:9139080-DNA Primers,
pubmed-meshheading:9139080-Female,
pubmed-meshheading:9139080-Flaviviridae,
pubmed-meshheading:9139080-Hepatitis,
pubmed-meshheading:9139080-Hepatitis, Viral, Human,
pubmed-meshheading:9139080-Hepatitis B,
pubmed-meshheading:9139080-Hepatitis C,
pubmed-meshheading:9139080-Humans,
pubmed-meshheading:9139080-Japan,
pubmed-meshheading:9139080-Liver Cirrhosis,
pubmed-meshheading:9139080-Male,
pubmed-meshheading:9139080-Middle Aged,
pubmed-meshheading:9139080-Molecular Sequence Data,
pubmed-meshheading:9139080-Polymerase Chain Reaction,
pubmed-meshheading:9139080-Prevalence,
pubmed-meshheading:9139080-RNA, Viral,
pubmed-meshheading:9139080-Sequence Homology, Amino Acid,
pubmed-meshheading:9139080-Sequence Homology, Nucleic Acid
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Infection with GB virus C in patients with chronic liver disease.
|
| pubmed:affiliation |
Department of Internal Medicine, Iwaki Kyoritsu General Hospital, Fukushima-Ken, Japan.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|