Linked Life Data

9137983

Source:http://linkedlifedata.com/resource/pubmed/id/9137983

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1997-7-25
pubmed:abstractText
The recent cloning of receptors for calcitonin (CT) and parathyroid hormone (PTH)/parathyroid hormone-related peptide (PTHrP) has enabled very rapid progress in understanding the molecular and cell biology of these receptors. In particular, much has been learnt about the tissue distribution of these receptors, as well as their mode of interaction with ligands, signal transduction and regulation of expression. The conventional view of these hormone-receptors systems as "calciotropic" has been broadened by recent work showing important developmental roles. Isoforms of the CT receptor (CTR), with interesting functional differences, have been identified and a new form of the PTH receptor, highly specific for PTH, has been cloned. Investigation of the homologous regulation of the CTR in osteoclasts by CT treatment of mouse marrow cultures, has shown that continuous exposure to CT results in formation of resorption competent, CTR-deficient osteoclasts. Treatment of mature osteoclasts causes a rapid and prolonged decrease in CTR mRNA levels, reflected in a loss of cell surface CTR. Since these cells regain resorption competence, the data support the concept that the clinical phenomenon of "escape" from the hypocalcemic action of CT results from a loss of CT sensitivity by osteoclasts to the hormone.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0018-5043
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
128-34
pubmed:dateRevised
2009-2-19
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Receptors of calciotropic hormones.
pubmed:affiliation
St. Vincent's Institute of Medical Research, Fitzroy, Australia.
pubmed:publicationType
Journal Article, Review