Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1997-5-20
pubmed:abstractText
Dendritic cells (DCs) play a critical role in capturing and presenting inhaled antigens to T lymphocytes. We report that pulmonary DCs in the Lewis rat are normally located in the lung in immediate proximity to nerve fibers that contain immunoreactive substance P (SP). Functionally, pulmonary DCs bound 125I-SP and displayed increased motility in vitro in response to graded concentrations of SP. However, SP had no effect on the accessory cell activities of DCs. To examine the role of neural influences on the pulmonary immune response to inhaled antigen, Lewis rats were pretreated with capsaicin (CAP), which damages small nerves and depletes neuropeptide stores, and then challenged intratracheally (i.t.) with hen egg lysozyme (HEL). The number and antigen-presenting cell activities of pulmonary DCs in the CAP-treated rats were comparable to those of controls up to day 14. T lymphocytes harvested from the regional lymph nodes draining the lung were effectively sensitized to HEL in both groups. However, when CAP-treated rats sensitized to HEL i.t. at day 0 were rechallenged with HEL i.t. at day 14, the lungs showed decreased numbers of OX-6+ DCs and diminished pulmonary lymphoid infiltrates compared with controls. We suggest that CAP interferes with a neural-mediated response that contributes to the accumulation of inflammatory cells during the efferent limb of the pulmonary-cell-mediated immune response in vivo.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9137097-1348482, http://linkedlifedata.com/resource/pubmed/commentcorrection/9137097-1352167, http://linkedlifedata.com/resource/pubmed/commentcorrection/9137097-1612288, http://linkedlifedata.com/resource/pubmed/commentcorrection/9137097-1740664, http://linkedlifedata.com/resource/pubmed/commentcorrection/9137097-1900424, http://linkedlifedata.com/resource/pubmed/commentcorrection/9137097-1910813, http://linkedlifedata.com/resource/pubmed/commentcorrection/9137097-2162904, http://linkedlifedata.com/resource/pubmed/commentcorrection/9137097-2175253, http://linkedlifedata.com/resource/pubmed/commentcorrection/9137097-2471450, http://linkedlifedata.com/resource/pubmed/commentcorrection/9137097-2582477, http://linkedlifedata.com/resource/pubmed/commentcorrection/9137097-2975354, http://linkedlifedata.com/resource/pubmed/commentcorrection/9137097-3511172, http://linkedlifedata.com/resource/pubmed/commentcorrection/9137097-3538958, http://linkedlifedata.com/resource/pubmed/commentcorrection/9137097-4589990, http://linkedlifedata.com/resource/pubmed/commentcorrection/9137097-6200231, http://linkedlifedata.com/resource/pubmed/commentcorrection/9137097-6989919, http://linkedlifedata.com/resource/pubmed/commentcorrection/9137097-7519212, http://linkedlifedata.com/resource/pubmed/commentcorrection/9137097-7527171, http://linkedlifedata.com/resource/pubmed/commentcorrection/9137097-7667288, http://linkedlifedata.com/resource/pubmed/commentcorrection/9137097-7689609, http://linkedlifedata.com/resource/pubmed/commentcorrection/9137097-7699319, http://linkedlifedata.com/resource/pubmed/commentcorrection/9137097-7802919, http://linkedlifedata.com/resource/pubmed/commentcorrection/9137097-8120392, http://linkedlifedata.com/resource/pubmed/commentcorrection/9137097-8217188, http://linkedlifedata.com/resource/pubmed/commentcorrection/9137097-8306037, http://linkedlifedata.com/resource/pubmed/commentcorrection/9137097-8426110, http://linkedlifedata.com/resource/pubmed/commentcorrection/9137097-8453173
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0002-9440
pubmed:author
pubmed:issnType
Print
pubmed:volume
150
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1735-43
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Pulmonary response to inhaled antigen: neuroimmune interactions promote the recruitment of dendritic cells to the lung and the cellular immune response to inhaled antigen.
pubmed:affiliation
Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.