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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1997-9-3
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pubmed:abstractText |
Meiotic recombination between artificial repeats positioned on nonhomologous chromosomes occurs efficiently in the yeast Saccharomyces cerevisiae. Both gene conversion and crossover events have been observed, with crossovers yielding reciprocal translocations. In the current study, 5.5-kb ura3 repeats positioned on chromosomes V and XV were used to examine the effect of ectopic recombination on meiotic chromosome segregation. Ura3 random spores were selected and gene conversion vs. crossover events were distinguished by Southern blot analysis. Approximately 15% of the crossover events between chromosomes V and XV were associated with missegregation of one of these chromosomes. The missegregation was manifest as hyperploid spores containing either both translocations plus a normal chromosome, or both normal chromosomes plus one of the translocations. In those cases where it could be analyzed, missegregation occurred at the first meiotic division. These data are discussed in terms of a model in which ectopic crossovers compete efficiently with normal allelic crossovers in directing meiotic chromosome segregation.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9136001-1608938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9136001-17246080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9136001-17246179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9136001-1913808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9136001-2203538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9136001-2249756,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9136001-2275802,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9136001-2421362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9136001-2653960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9136001-3319781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9136001-3535068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9136001-3539696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9136001-3542721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9136001-3549449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9136001-3606589,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9136001-3889906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9136001-5807333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9136001-6364963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9136001-7893122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9136001-7954796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9136001-797314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9136001-8122905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9136001-8274856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9136001-8431941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9136001-8436265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9136001-8825482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9136001-8878672
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0016-6731
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
146
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
69-78
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pubmed:dateRevised |
2010-9-13
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pubmed:meshHeading |
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pubmed:year |
1997
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pubmed:articleTitle |
Meiotic crossing over between nonhomologous chromosomes affects chromosome segregation in yeast.
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pubmed:affiliation |
Department of Biology, Emory University, Atlanta, Georgia 30322, USA. jinks@biology.emory.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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