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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1997-5-13
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pubmed:abstractText |
We previously identified a putative signal transducing adaptor molecule, named STAM, that contains an Src homology 3 (SH3) domain and immunoreceptor tyrosine-based activation motif (ITAM). In this report, we demonstrate the functional significance of STAM in cytokine-mediated signal transduction. STAM is associated with Jak3 and Jak2 tyrosine kinases via its ITAM region and phosphorylated by Jak3 and Jak2 upon stimulation with IL-2 and GM-CSF, respectively. An SH3 deletion mutant of STAM confers a dominant-negative effect on DNA synthesis mediated by IL-2 and GM-CSF. Furthermore, the wild-type STAM, but not STAM mutants deleted of SH3 and ITAM, significantly enhances c-myc induction mediated by IL-2 and GM-CSF. These results strongly implicate STAM in the signaling pathways for cell growth and c-myc induction immediately downstream of the Jaks associated with the cytokine receptors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Endosomal Sorting Complexes...,
http://linkedlifedata.com/resource/pubmed/chemical/Granulocyte-Macrophage...,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/JAK2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/JAK3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Jak2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Jak3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Janus Kinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Janus Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/STAM protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Stam protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1074-7613
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
449-57
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9133424-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:9133424-Animals,
pubmed-meshheading:9133424-Cell Division,
pubmed-meshheading:9133424-DNA,
pubmed-meshheading:9133424-Endosomal Sorting Complexes Required for Transport,
pubmed-meshheading:9133424-Gene Expression Regulation,
pubmed-meshheading:9133424-Genes, myc,
pubmed-meshheading:9133424-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:9133424-Humans,
pubmed-meshheading:9133424-Interleukin-2,
pubmed-meshheading:9133424-Janus Kinase 2,
pubmed-meshheading:9133424-Janus Kinase 3,
pubmed-meshheading:9133424-Mice,
pubmed-meshheading:9133424-Mutation,
pubmed-meshheading:9133424-Phosphoproteins,
pubmed-meshheading:9133424-Phosphorylation,
pubmed-meshheading:9133424-Protein-Tyrosine Kinases,
pubmed-meshheading:9133424-Proto-Oncogene Proteins,
pubmed-meshheading:9133424-Receptors, Interleukin-2,
pubmed-meshheading:9133424-Signal Transduction,
pubmed-meshheading:9133424-Transfection,
pubmed-meshheading:9133424-Tumor Cells, Cultured,
pubmed-meshheading:9133424-Tyrosine,
pubmed-meshheading:9133424-src Homology Domains
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pubmed:year |
1997
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pubmed:articleTitle |
STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction.
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pubmed:affiliation |
Department of Microbiology, Tohoku University School of Medicine, Sendai, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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