Linked Life Data

9132980

Source:http://linkedlifedata.com/resource/pubmed/id/9132980

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1997-5-1
pubmed:abstractText
Failure of uncomplicated gonococcal infections acquired in the Far East to respond to doses of ciprofloxacin and ofloxacin recommended by the Centers for Disease Control and Prevention have been identified in Australia, the United Kingdom, and the United States. In the Republic of the Philippines, 54.3% of strains exhibited decreased susceptibility to fluoroquinolones; 12% of strains were resistant to ciprofloxacin. This study was undertaken to compare the antimicrobial susceptibilities of gonococcal isolates in Bangkok, Thailand, with those in the Republic of the Philippines.
pubmed:keyword
http://linkedlifedata.com/resource/pubmed/keyword/Asia, http://linkedlifedata.com/resource/pubmed/keyword/Clinical Research, http://linkedlifedata.com/resource/pubmed/keyword/Developing Countries, http://linkedlifedata.com/resource/pubmed/keyword/Diseases, http://linkedlifedata.com/resource/pubmed/keyword/Drugs--therapeutic use, http://linkedlifedata.com/resource/pubmed/keyword/GONORRHEA, http://linkedlifedata.com/resource/pubmed/keyword/Infections, http://linkedlifedata.com/resource/pubmed/keyword/Reproductive Tract Infections, http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology, http://linkedlifedata.com/resource/pubmed/keyword/Sexually Transmitted Diseases, http://linkedlifedata.com/resource/pubmed/keyword/Southeastern Asia, http://linkedlifedata.com/resource/pubmed/keyword/THAILAND, http://linkedlifedata.com/resource/pubmed/keyword/Treatment
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0148-5717
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
142-8
pubmed:dateRevised
2003-11-14
pubmed:otherAbstract
PIP: To assess the frequency and diversity of antimicrobial resistant strains of Neisseria gonorrhoeae in Thailand, endocervical or urethral strains were isolated from 101 patients at a Bangkok sexually transmitted disease clinic. Of the 101 strains, 90 (89.1%) were resistant to penicillin or tetracycline. Plasmid-mediated resistance to penicillin or tetracycline was found in 33.7% of isolates; this included penicillinase-producing N gonorrhoeae (17.8%), tetracycline-resistant N gonorrhoeae (7.9%), and penicillinase-producing/tetracycline-resistant N gonorrhoeae (7.9%). Moreover, 51.5% of all strains exhibited chromosomally mediated resistance to penicillin and tetracycline. All strains were susceptible to spectinomycin. 22 strains (21.8%) showed decreased susceptibility to ciprofloxacin, while another fifth demonstrated resistance to both fluoroquinolones and norfloxacin. Finally, more than 75% of strains exhibited decreased susceptibility to kanamycin and thiamphenicol. The penicillin/tetracycline resistance phenotypes identified in Bangkok were more similar to those of isolates in the US than in the Philippines, where decreased susceptibility to fluoroquinolones predominates. Given evidence of antimicrobial resistance to penicillin, tetracycline, kanamycin, thiamphenicol, and fluoroquinolones in Thailand, the choice of agents for the treatment of uncomplicated gonococcal infection should be considered carefully and periodic surveillance of antimicrobial resistance is recommended to permit timely revision of treatment protocols.
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Antimicrobial susceptibilities of strains of Neisseria gonorrhoeae in Bangkok, Thailand: 1994-1995.
pubmed:affiliation
Division of AIDS, STD, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
pubmed:publicationType
Journal Article