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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1997-5-1
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pubmed:abstractText |
To date, only a small percentage of human genes have been cloned and mapped. To facilitate more rapid gene mapping and disease gene isolation, chromosome 5-specific cDNA libraries have been constructed from five sources. DNA sequencing and regional mapping of 205 unique cDNAs indicates that 25 are from known chromosome 5 genes and 138 are from new chromosome 5 genes (a frequency of 79.5%). Sequence complexity estimates indicate that each library contains -20% of the approximately 5000 genes that are believed to reside on chromosome 5. This study more than doubles the number of genes mapped to chromosome 5 and describes an important new tool for disease gene isolation.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1088-9051
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
185-94
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9132272-Base Sequence,
pubmed-meshheading:9132272-Chromosome Mapping,
pubmed-meshheading:9132272-Chromosomes, Human, Pair 5,
pubmed-meshheading:9132272-DNA, Complementary,
pubmed-meshheading:9132272-Gene Library,
pubmed-meshheading:9132272-Genome, Human,
pubmed-meshheading:9132272-HeLa Cells,
pubmed-meshheading:9132272-Humans,
pubmed-meshheading:9132272-Molecular Sequence Data,
pubmed-meshheading:9132272-RNA
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pubmed:year |
1995
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pubmed:articleTitle |
Human chromosome-specific cDNA libraries: new tools for gene identification and genome annotation.
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pubmed:affiliation |
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235-8591, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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