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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1997-7-1
|
| pubmed:databankReference | |
| pubmed:abstractText |
We found previously that Kuwaiti HTLV-I isolates had two nucleotide substitutions in the most frequently sequenced regions of HTLV-I genome, namely: T-->C 4783 in the pol and T-->C 6569 the env genes. These substitutions were observed rarely in other HTLV-I isolates and seemed to be good markers of the HTLV-I lineage, the "epicentre" of which was located in Mashhad, Iran. To test this hypothesis we sequenced the fragments of HTLV-I genome including sites 4783 and 6569 from seven isolates obtained from the Iranians either living in (five isolates) or originating from (two isolates) Mashhad. RFLP-based tests were also designed and used for typing of the substitutions. All seven isolates were positive for T-->C 4783 and six, from which env fragment was amplifiable, were also positive for T-->C 6569. It is highly probable that all the isolates from Mashhadi Jews belong to the same HTLV-I lineage, although they were not typed yet for the presence of T-->C 6569 substitution. Only 2 "non-Middle Eastern" HTLV-1, both from La Réunion Island were positive for both of the substitutions. Another possible member of Mashhadi lineage of HTLV-I is one isolate from southern India and two isolates from the American Indians, British Columbia, Canada. The determination of the T-->C 4783 and T-->C 6569 markers in HTLV-I isolates of different geographical/ethnic origin may be useful for the reconstruction of the routes of HTLV-I spread from the Middle East and/or Indian subcontinent to other regions of the world and, possibly, for gaining insights into the origin of HTLV-I in Asia.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0146-6615
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
52
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
77-82
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9131461-Adult,
pubmed-meshheading:9131461-Aged,
pubmed-meshheading:9131461-Female,
pubmed-meshheading:9131461-Genes, env,
pubmed-meshheading:9131461-Genes, pol,
pubmed-meshheading:9131461-HTLV-I Infections,
pubmed-meshheading:9131461-Human T-lymphotropic virus 1,
pubmed-meshheading:9131461-Humans,
pubmed-meshheading:9131461-Iran,
pubmed-meshheading:9131461-Israel,
pubmed-meshheading:9131461-Kuwait,
pubmed-meshheading:9131461-Male,
pubmed-meshheading:9131461-Middle Aged,
pubmed-meshheading:9131461-Molecular Sequence Data,
pubmed-meshheading:9131461-Phylogeny,
pubmed-meshheading:9131461-Point Mutation,
pubmed-meshheading:9131461-Polymerase Chain Reaction,
pubmed-meshheading:9131461-Reunion,
pubmed-meshheading:9131461-Sequence Analysis, DNA
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Common origin of human T-lymphotropic virus type-I from Iran, Kuwait, Israel, and La Réunion Island.
|
| pubmed:affiliation |
Department of Microbiology, Faculty of Medicine, Kuwait University, Kuwait.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|